• Publications
  • Influence
Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade.
  • S. Dudek, M. Bear
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 15 May 1992
We tested a theoretical prediction that patterns of excitatory input activity that consistently fail to activate target neurons sufficiently to induce synaptic potentiation will instead cause aExpand
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Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice
Obsessive-compulsive disorder (OCD) is an anxiety-spectrum disorder characterized by persistent intrusive thoughts (obsessions) and repetitive actions (compulsions). Dysfunction ofExpand
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Bidirectional long-term modification of synaptic effectiveness in the adult and immature hippocampus
  • S. Dudek, M. Bear
  • Chemistry, Medicine
  • The Journal of neuroscience : the official…
  • 1 July 1993
Previously we showed that delivering 900 pulses to the Schaffer collateral-CA1 pathway at 1–3 Hz causes a lasting depression of synaptic effectiveness that is input specific and dependent on NMDAExpand
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Common forms of synaptic plasticity in the hippocampus and neocortex in vitro.
Activity-dependent synaptic plasticity in the superficial layers of juvenile cat and adult rat visual neocortex was compared with that in adult rat hippocampal field CA1. Stimulation of neocorticalExpand
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WRP/srGAP3 Facilitates the Initiation of Spine Development by an Inverse F-BAR Domain, and Its Loss Impairs Long-Term Memory
The WAVE-associated Rac GAP, WRP, is thought to regulate key aspects of synapse development and function and may be linked to mental retardation in humans. WRP contains a newly described inverseExpand
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Synaptic Plasticity (and the Lack Thereof) in Hippocampal CA2 Neurons
The hippocampus is critical for some forms of memory and spatial navigation, but previous research has mostly neglected the CA2, a unique region situated between CA3 and CA1. Here, we show that CA2Expand
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Rediscovering area CA2: unique properties and functions
Hippocampal area CA2 has several features that distinguish it from CA1 and CA3, including a unique gene expression profile, failure to display long-term potentiation and relative resistance to cellExpand
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Rapid activity-induced transcription of Arc and other IEGs relies on poised RNA polymerase II
Transcription of immediate early genes (IEGs) in neurons is highly sensitive to neuronal activity, but the mechanism underlying these early transcription events is largely unknown. We found thatExpand
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Perineuronal Nets Suppress Plasticity of Excitatory Synapses on CA2 Pyramidal Neurons
Long-term potentiation of excitatory synapses on pyramidal neurons in the stratum radiatum rarely occurs in hippocampal area CA2. Here, we present evidence that perineuronal nets (PNNs), aExpand
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RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory
Learning and memory have been closely linked to strengthening of synaptic connections between neurons (i.e., synaptic plasticity) within the dentate gyrus (DG)–CA3–CA1 trisynaptic circuit of theExpand
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