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Atypical and malignant solitary fibrous tumors in extrathoracic locations: evidence of their comparability to intra-thoracic tumors.
TLDR
It is demonstrated that nuclear atypia, hypercellularity, greater than 4 mitoses/10 HPFs, and necrosis may be seen in up to 10% of extrathoracic SFTs, and are associated with, but are not by themselves predictive of, aggressive clinical behavior. Expand
Low-grade myofibroblastic sarcoma: analysis of 18 cases in the spectrum of myofibroblastic tumors.
TLDR
Low-grade myofibroblastic sarcoma seems to represent a distinct entity in the spectrum of low-gradeMyofibrosarcoma neoplasms and is distinguishable from fibromatosis, my ofibrom atosis, solitary fibrous tumor, fibrosar coma, and leiomyosarcomA. Expand
Diagnosis and management of synovial sarcoma
TLDR
Although ifosfamide based chemotherapy has been associated with an improved survival in patients with synovial sarcoma, the search for less toxic and more targeted systemic therapies is ongoing. Expand
Advanced hepatic ablation technique for creating complete cell death: irreversible electroporation.
TLDR
In an animal model, IRE proved to be a fast, safe, and potent ablative method, causing complete tissue death by means of apoptosis, suggesting involvement of the apoptotic process in the pathophysiology of cell death caused by IRE. Expand
Genome‐wide transcriptome analyses reveal p53 inactivation mediated loss of miR‐34a expression in malignant peripheral nerve sheath tumours
TLDR
The data show that p53 inactivation and subsequent loss of expression of miR‐34a may significantly contribute to the MPNST development and suggest that deregulation of miRNAs has a potential role in the malignant transformation process in peripheral nerve sheath tumours. Expand
Beneficial Endocrine but Adverse Exocrine Effects of Sitagliptin in the Human Islet Amyloid Polypeptide Transgenic Rat Model of Type 2 Diabetes
TLDR
The combination of metformin and sitagliptin had synergistic actions to preserve β-cell mass and function and enhance insulin sensitivity in the HIP rat model of type 2 diabetes, however, adverse actions of sitgliptin treatment on exocrine pancreas raise concerns that require further evaluation. Expand
PTEN loss accelerates KrasG12D-induced pancreatic cancer development.
TLDR
A dosage-dependent role for PTEN, and the resulting dysregulation of the PI3K/AKT signaling axis, is supported in both PDAC initiation and progression, and shed additional light on the signaling mechanisms that lead to the development of ADM and subsequent mPanIN and pancreatic cancer. Expand
Malignant Peripheral Nerve Sheath Tumor.
TLDR
Tumor size and fludeoxyglucose F 18 avidity are among the most helpful parameters to distinguish MPNST from a benign peripheral nerve sheath tumor. Expand
PTEN dosage is essential for neurofibroma development and malignant transformation
TLDR
Using noninvasive in vivo PET-CT imaging, it is demonstrated that FDG can be used to identify the malignant transformation in both murine and human MPNSTs and combined inhibition of RAS/RAF/MAPK and PTEN/PI3K/AKT pathways may be beneficial for patients withMPNST. Expand
Ossifying Fibromyxoid Tumor of Soft Parts: A Clinicopathologic, Proteomic, and Genomic Study
TLDR
It is concluded that malignant of soft tissue and bone tumor of borderline malignancy exist and may be recognized by the previously proposed criteria of Folpe and Weiss. Expand
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