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The Mechanism of Mitochondrial Superoxide Production by the Cytochrome bc1 Complex*
It is concluded that cytochrome bc1 complex-linked ROS production is primarily promoted by a partially oxidized rather than by a fully reduced ubiquinone pool, which offers a straightforward explanation of how the redox state of the ubiquin one pool could play a central role in mitochondrial redox signaling.
Molecular mechanisms of superoxide production by the mitochondrial respiratory chain.
A detailed understanding of the molecular mechanisms driving these enzymes is required to understand mitochondrial ROS production during oxidative stress and redox signalling.
Mitochondrial Telomerase Reverse Transcriptase Binds to and Protects Mitochondrial DNA and Function From Damage
It is demonstrated that TERT is localized in the matrix of the mitochondria, which exerts a novel protective function by binding to mitochondrial DNA, increasing respiratory chain activity and protecting against oxidative stress–induced damage.
Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases.
Two groups of the plecomacrolide-defined class of macrolide antibiotics are recognized as important tools for studying the physiological role of vacuolar-type, proton-translocating ATPases and ATPases with phosphorylated states in animal and plant cells as well as in yeast, fungi and bacteria.
Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice
- V. Rhein, Xiaomin Song, A. Eckert
- Biology, ChemistryProceedings of the National Academy of Sciences
- 24 November 2009
A molecular link between Aβ and tau protein in AD pathology in vivo is established, illustrating the potential of quantitative proteomics and establishing synergistic, age-associated effects of A β and t Tau in perishing mitochondria.
Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases.
- S. Dröse, K. Bindseil, E. J. Bowman, A. Siebers, A. Zeeck, K. Altendorf
- 20 April 1993
The structure-activity study showed that in general the concanamycins, 18-membered macrolides, are better and more specific inhibitors than the bafilomycins of this class of membrane-bound ATPases.
Proteomic and Functional Analyses Reveal a Mitochondrial Dysfunction in P301L Tau Transgenic Mice*
Tau pathology involves a mitochondrial and oxidative stress disorder possibly distinct from that caused by Aβ, and P301L tau mitochondria displayed increased vulnerability toward β-amyloid (Aβ) peptide insult, suggesting a synergistic action of tau and Aβ pathology on the mitochondria.
Complexome profiling identifies TMEM126B as a component of the mitochondrial complex I assembly complex.
Superoxide generation by complex III: from mechanistic rationales to functional consequences.
Differential effects of complex II on mitochondrial ROS production and their relation to cardioprotective pre- and postconditioning.
- S. Dröse
- BiologyBiochimica et biophysica acta
- 1 May 2013