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Branched siloxanes as possible new heat transfer fluids for application in parabolic through solar thermal power plants
Drug Design Based on the Carbon/Silicon Switch Strategy
Silicon chemistry has been demonstrated to be a novel source of chemical diversity in drug design. The carbon/silicon switch strategy, i.e., the strategic replacement of a carbon atom with a silicon…
Disila-analogues of the synthetic retinoids EC23 and TTNN: synthesis, structure and biological evaluation.
- Josef B. G. Gluyas, C. Burschka, S. Doerrich, Judith Vallet, H. Gronemeyer, R. Tacke
- ChemistryOrganic & biomolecular chemistry
- 8 August 2012
In this study, the biological effects of a two-fold sila-substitution in the synthetic retinoids EC23 and TTNN and their corresponding analogues with an indane instead of a 1,2,3,4-tetrahydronaphthalene skeleton were investigated, resulting in considerably different effects.
Novel Silicon‐Containing Analogues of the Retinoid Agonist Bexarotene: Syntheses and Biological Effects on Human Pluripotent Stem Cells
Preliminary evidence indicates that disila‐bexarotene and its analogues 8 and 9 may possess enhanced functions over the parent compound bexarotenes, such as induction and regulation of cell death and cell numbers.
Disila-galaxolide and derivatives: synthesis and olfactory characterization of silicon-containing derivatives of the musk odorant galaxolide.
The introduction of a 7-methylene group in disila-galaxolide (4 b→rac-9) improved the odor threshold by a factor of two and the presumed hydrophobic bulk binding pocket of the corresponding musk receptor(s) could be characterized in more detail, which could be useful for the design of novel musk odorants with an improved environmental profile.
High‐Affinity, Selective σ Ligands of the 1,2,3,4‐Tetrahydro‐1,4′‐silaspiro[naphthalene‐1,4′‐piperidine] Type: Syntheses, Structures, and Pharmacological Properties
The σ1/σ2 selectivity of the silicon compounds is considerably improved, indicating that the C→Si switch strategy is a powerful tool for modulating both pharmacological potency and selectivity.
Evidence for a shape-based recognition of odorants in vivo in the human nose from an analysis of the molecular mechanism of lily-of-the-valley odorants detection in the Lilial and Bourgeonal family…
It is suggested that odorant detection under threshold conditions is mainly based on the molecular shape, i.e. the van der Waals surface, and electrostatics of the odorants.
X-ray Crystallographic and NMR Spectroscopic Study of (η2-Alkene)(μ-alkyne)pentacarbonyldicobalt Complexes: Arrested Pauson−Khand Reaction Intermediates
The hexacarbonyldicobalt complexes of a range of 5-alkynyl-5H-dibenzo[a,d]cycloheptenes, 11a−e, readily undergo loss of a carbonyl ligand with concomitant formation of pentacarbonyldicobalt clusters,…
Synthesis and Olfactory Characterization of Sila-Methyl Pamplemousse and Related Odorants with a 2,2,5-Trimethyl-2-silahex-4-ene Skeleton
The synthetic grapefruit odorant methyl pamplemousse (1a) has lately become an important trend odorant, and the related 2,2,5-trimethylhex-4-enes 2a–4a also possess interesting olfactory properties…
Sila‐α‐galbanone and Analogues: Synthesis and Olfactory Characterization of Silicon‐Containing Derivatives of the Galbanum Odorant α‐Galbanone
Silicon compounds 1b–3b are sila-analogues of the galbanum odorants α-galbanone (1a), α-spirogalbanone (2a), and nor-α-galbanone (3a), respectively. Sila-α-galbanone (1b), sila-α-spirogalbanone (2b),…