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Crystal Structure of the Tyrosine Phosphatase SHP-2
The structure of the SHP-2 tyrosine phosphatase, determined at 2.0 angstroms resolution, shows how its catalytic activity is regulated by its two SH2 domains. In the absence of aExpand
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Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1
Epigenetic inheritance in mammals is characterized by high-fidelity replication of CpG methylation patterns during development. UHRF1 (also known as ICBP90 in humans and Np95 in mouse) is an E3Expand
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Structure of the IRS-1 PTB Domain Bound to the Juxtamembrane Region of the Insulin Receptor
SUMMARY Crystal structures of the insulin receptor substrate-1 (IRS-1) phosphotyrosine-binding (PTB) domain, alone and complexed with the juxtamembrane region of the insulin receptor, show how thisExpand
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Protein production and purification
NOTE: In the version of this Review initially published, an author (B. Martin Hallberg) was left off of the author list. This information has been added to the HTML and PDF versions of the Review.InExpand
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Structure of the Globular Tail of Nuclear Lamin*
The nuclear lamins form a two-dimensional matrix that provides integrity to the cell nucleus and participates in nuclear activities. Mutations in the region of human LMNAencoding theExpand
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Protein Aggregates Are Recruited to Aggresome by Histone Deacetylase 6 via Unanchored Ubiquitin C Termini*
Background: Misfolded protein aggregates are recruited to the aggresome by a protein complex consisting of histone deacetylase 6 (HDAC6). Results: The ubiquitin-binding domain (ZnF-UBP) of HDAC6Expand
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Crystal Structure of the HNF4α Ligand Binding Domain in Complex with Endogenous Fatty Acid Ligand*
HNF4α is an orphan member of the nuclear receptor family with prominent functions in liver, gut, kidney and pancreatic β cells. We have solved the x-ray crystal structure of the HNF4α ligand bindingExpand
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FKBP Family Proteins: Immunophilins with Versatile Biological Functions
Immunophilins consist of a family of highly conserved proteins binding with immunosuppressive drugs such as FK506, rapamycin and cyclosporin A. FK506-binding protein (FKBP) is one of two majorExpand
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Amino-terminal Dimerization, NRDP1-Rhodanese Interaction, and Inhibited Catalytic Domain Conformation of the Ubiquitin-specific Protease 8 (USP8)*
Ubiquitin-specific protease 8 (USP8) hydrolyzes mono and polyubiquitylated targets such as epidermal growth factor receptors and is involved in clathrin-mediated internalization. In 1182 residues,Expand
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Phthalimide conjugation as a strategy for in vivo target protein degradation
A degrading game plan for cancer therapy Certain classes of proteins that contribute to cancer development are challenging to target therapeutically. Winter et al. devised a chemical strategy that,Expand
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