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Improvement of Cardiac Function by a Cardiac Myosin Activator in Conscious Dogs With Systolic Heart Failure
Background—Therapy for chronic systolic heart failure (sHF) has improved over the past 2 decades, but the armamentarium of drugs is limited and consequently sHF remains a leading cause of death andExpand
Proteasome inhibition decreases cardiac remodeling after initiation of pressure overload.
We tested the possibility that proteasome inhibition may reverse preexisting cardiac hypertrophy and improve remodeling upon pressure overload. Mice were submitted to aortic banding and followed upExpand
Concurrent Vision Dysfunctions in Convergence Insufficiency With Traumatic Brain Injury
Purpose This study assessed the prevalence of convergence insufficiency (CI) with and without simultaneous vision dysfunctions within the traumatic brain injury (TBI) sample population becauseExpand
Choledochal Cysts in Children and Adults with Contrasting Profiles: 11-Year Experience at a Tertiary Care Center in Kashmir
BackgroundCholedochal cyst is a surgical problem usually related to infancy and childhood. Despite advancements in management, a large number of cases still present during adulthood. The clinicalExpand
Effects of cardiac overexpression of type 6 adenylyl cyclase affects on the response to chronic pressure overload.
Adenylyl cyclase (AC) type 5 (AC5) and AC type 6 (AC6) are the two major AC isoforms in the heart. Cardiac overexpression of AC6 has been shown to be protective in response to several interventions.Expand
Preemptive conditioning of the swine heart by H11 kinase/Hsp22 provides cardiac protection through inducible nitric oxide synthase.
The second window of ischemic preconditioning (SWOP) provides maximal protection against ischemia through regulation of the inducible nitric oxide synthase (iNOS), yet its application is limited byExpand
Two somali half‐siblings with CHST3‐related chondrodysplasia illustrating the phenotypic spectrum and intrafamilial variability
Deficiency of carbohydrate sulfotransferase 3 (CHST3; also known as chondroitin‐6‐sulfotranferase) has been associated with a phenotype of severe chondrodysplasia and progressive spinal involvement.Expand
Natriuretic peptides and heart failure in the patient with chronic kidney disease: a review of current evidence
Natriuretic peptides such as brain natriuretic peptide (BNP) and N-terminal pro-BNP (NT-proBNP) are commonly used in the diagnosis and evaluation of heart failure. However, their utility in patientsExpand
Sexual dimorphism in cardiac triacylglyceride dynamics in mice on long term caloric restriction.
Human studies indicate augmented myocardial lipid metabolism in females, and that sex and obesity interact to predict myocardial fatty acid oxidation and storage. Altered lipid dynamics precedeExpand
Transient Apical Ballooning: Sheep in Wolves’ Garb
Takotsubo cardiomyopathy is a unique acute cardiac syndrome characterized by typical ischemic chest symptoms, an elevated ST segment on the electrocardiogram, and elevated cardiac disease markers. ItExpand