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Catalytic asymmetric synthesis.
On the mechanism of the Skraup-Doebner-Von Miller quinoline synthesis.
The mechanism of the formation of substituted quinolines from anilines and alpha,beta-unsaturated ketones has been studied by the use of 13C-labeled ketones in cross-over experiments. In the reaction… Expand
Lewis base catalysis in organic synthesis.
The legacy of Gilbert Newton Lewis (1875-1946) pervades the lexicon of chemical bonding and reactivity. The power of his concept of donor-acceptor bonding is evident in the eponymous foundations of… Expand
Total synthesis of RK-397.
An enantioselective synthesis of the polyene macrolide RK-397 is described. The use of the same eight-carbon building block twice for the construction of the polyol chain allowed for a highly… Expand
A comparison of (chloromethyl)- and (iodomethyl)zinc cyclopropanation reagents
Intramolecular silicon-assisted cross-coupling: total synthesis of (+)-brasilenyne.
The first, total synthesis of (+)-brasilenyne (1) has been achieved in 19 steps from l-(S)-malic acid. The key elements of this approach are a highly diastereoselective ring-opening of a… Expand
Topics in Stereochemistry: Denmark/Topics in Stereochemistry, V25
Solution- and solid-state structural studies of (halomethyl)zinc reagents
(Halomethyl)zinc cyclopropanation reagents have been investigated by solution NMR and X-ray crystallographic methods. Treatment of glycol-ether complexes of diethylzinc with chloroiodomethane or… Expand
Organocerium Additions to Chiral α,α-Dialkoxy Hydrazones: Asymmetric Synthesis of N-Protected α-Amino Acetals and α-Amino Aldehydes
A general and selective procedure for the diastereoselective additions of organocerium reagents to chiral α,α-dialkoxy hydrazones has been developed. The best reagent combination involved a 6:1… Expand