• Publications
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Catalytic asymmetric synthesis.
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On the mechanism of the Skraup-Doebner-Von Miller quinoline synthesis.
The mechanism of the formation of substituted quinolines from anilines and alpha,beta-unsaturated ketones has been studied by the use of 13C-labeled ketones in cross-over experiments. In the reactionExpand
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Lewis base catalysis in organic synthesis.
The legacy of Gilbert Newton Lewis (1875-1946) pervades the lexicon of chemical bonding and reactivity. The power of his concept of donor-acceptor bonding is evident in the eponymous foundations ofExpand
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Total synthesis of RK-397.
An enantioselective synthesis of the polyene macrolide RK-397 is described. The use of the same eight-carbon building block twice for the construction of the polyol chain allowed for a highlyExpand
  • 94
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Intramolecular silicon-assisted cross-coupling: total synthesis of (+)-brasilenyne.
  • S. Denmark, S. Yang
  • Chemistry, Medicine
  • Journal of the American Chemical Society
  • 27 November 2002
The first, total synthesis of (+)-brasilenyne (1) has been achieved in 19 steps from l-(S)-malic acid. The key elements of this approach are a highly diastereoselective ring-opening of aExpand
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Solution- and solid-state structural studies of (halomethyl)zinc reagents
(Halomethyl)zinc cyclopropanation reagents have been investigated by solution NMR and X-ray crystallographic methods. Treatment of glycol-ether complexes of diethylzinc with chloroiodomethane orExpand
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Organocerium Additions to Chiral α,α-Dialkoxy Hydrazones: Asymmetric Synthesis of N-Protected α-Amino Acetals and α-Amino Aldehydes
A general and selective procedure for the diastereoselective additions of organocerium reagents to chiral α,α-dialkoxy hydrazones has been developed. The best reagent combination involved a 6:1Expand
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