• Publications
  • Influence
Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids
TLDR
The results identify several novel loci associated with plasma lipids that are also associated with CAD and provide the foundation to develop a broader biological understanding of lipoprotein metabolism and to identify new therapeutic opportunities for the prevention of CAD. Expand
Common variants at 30 loci contribute to polygenic dyslipidemia
TLDR
The results suggest that the cumulative effect of multiple common variants contributes to polygenic dyslipidemia. Expand
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
TLDR
Mendelian randomisation analyses challenge the concept that raising of plasma HDL cholesterol will uniformly translate into reductions in risk of myocardial infarction. Expand
Twenty bone mineral density loci identified by large-scale meta-analysis of genome-wide association studies
TLDR
The many SNPs associated with BMD map to genes in signaling pathways with relevance to bone metabolism and highlight the complex genetic architecture that underlies osteoporosis and variation in BMD. Expand
Offspring's Leukocyte Telomere Length, Paternal Age, and Telomere Elongation in Sperm
TLDR
For every additional year of paternal age, LTL in offspring increased at a magnitude ranging from half to more than twice of the annual attrition in LTL with age, a phenomenon which might relate to telomere elongation in sperm from older men. Expand
Functional Variant of CYP4A11 20-Hydroxyeicosatetraenoic Acid Synthase Is Associated With Essential Hypertension
TLDR
The association of the T8590C variant with hypertension supports its role as a polygenic determinant of blood pressure control in humans, and results obtained from the large population database suggest that the relevance of the variant may vary according to hypertension comorbidity. Expand
Genome-wide association with bone mass and geometry in the Framingham Heart Study
TLDR
The FHS 100K SNP project offers an unbiased genome-wide strategy to identify new candidate loci and to replicate previously suggested candidate genes for osteoporosis, as well as a open-access results resource at http://www.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?id=phs000007. Expand
Collaborative Meta-analysis: Associations of 150 Candidate Genes With Osteoporosis and Osteoporotic Fracture
TLDR
This analysis of genome-wide association results from 5 large populations found many common genetic variants that have robust statistical evidence for association with various traits and diseases, including osteoporosis. Expand
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
TLDR
A meta-analysis of genome-wide association studies of coronary artery disease comprising 22,233 individuals with CAD and 64,762 controls of European descent followed by genotyping of top association signals found 13 loci newly associated with CAD at P < 5 × 10−8 and confirmed the association of 10 of 12 previously reported CAD loci. Expand
Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study
TLDR
Observations suggest that hypertension, increased insulin resistance and oxidative stress are associated with shorter leukocyte telomere length and that shorterLeukocytes telomeres length in hypertensives is largely due to insulin resistance. Expand
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