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A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories
It is shown that whereas mutant mice exhibit early LTP in the dentate gyrus, late LTP is absent when measured 24 and 48 hours after tetanus in the freely moving animal, and Zif268 is essential for the transition from short-to-long-term synaptic plasticity and for the expression of long-term memories.
The MAPK/ERK Cascade Targets Both Elk-1 and cAMP Response Element-Binding Protein to Control Long-Term Potentiation-Dependent Gene Expression in the Dentate Gyrus In Vivo
- S. Davis, P. Vanhoutte, C. Pagès, J. Caboche, S. Laroche
- BiologyThe Journal of Neuroscience
- 15 June 2000
It is suggested that Elk-1 forms an important link in the MAP kinase pathway to transduce signals from the cell surface to the nucleus to activate the genetic machinery necessary for the maintenance of synaptic plasticity in the dentate gyrus.
Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy
This article critically discusses the challenges and opportunities for improving cognition in individuals suffering from psychiatric disorders, highlighting the needs to characterize the cellular and cerebral circuits underpinning cognitive function and identify more effective treatments.
Long-Term Potentiation Enhances Neurogenesis in the Adult Dentate Gyrus
The results indicate that electrically induced LTP in the dentate gyrus in vivo provides a cellular/molecular environment that favors both proliferation and survival of adult-generated neurons.
How necessary is the activation of the immediate early gene zif268 in synaptic plasticity and learning?
Plasticity at hippocampal to prefrontal cortex synapses: Dual roles in working memory and consolidation
The available evidence suggests that functional interactions between the hippocampus and prefrontal cortex in cognition and memory are more complex than previously anticipated, with the possibility for bidirectional regulation of synaptic strength as a function of the specific demands of tasks.
The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro
It is established that D-AP5 impairs spatial learning in a linear dose-dependent manner, highly correlated with its corresponding impairment of hippocampal LTP in vivo, and support is offered for the hypothesis that activation of NMDA receptors is necessary for certain kinds of learning.
Signalling mechanisms mediated by the phosphoinositide 3‐kinase/Akt cascade in synaptic plasticity and memory in the rat
Activation of the PI3K/Akt pathway may contribute to the mechanisms of synaptic plasticity and memory consolidation by promoting cell survival via FKHR and protein synthesis via mTOR.
MAPK, CREB and zif268 are all required for the consolidation of recognition memory.
- B. Bozon, Á. Kelly, S. Josselyn, Alcino J. Silva, S. Davis, S. Laroche
- BiologyPhilosophical transactions of the Royal Society…
- 29 April 2003
It is shown that pharmacological blockade of MAPK/ERK phosphorylation, functional inactivation of CREB in an inducible transgenic mouse and in activation of zif268 in a mutant mouse result in a similar deficit in long-term recognition memory.
Activation of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase in Hippocampal Circuitry Is Required for Consolidation and Reconsolidation of Recognition Memory
The data show that the MAPK kinase pathway is required for both consolidation and reconsolidation of long-term recognition memory, and that this is associated with hyperphosphorylation of ERK in different subregions of the entorhinal cortex—hippocampal circuitry.