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Postmenopausal hormone therapy: an Endocrine Society scientific statement.
TLDR
A scholarly review of the published literature on menopausal hormonal therapy (MHT), make scientifically valid assessments of the available data, and grade the level of evidence available for each clinically important endpoint to arrive at major conclusions.
Androgen levels in adult females: changes with age, menopause, and oophorectomy.
TLDR
It is reported that serum androgen levels decline steeply in the early reproductive years and do not vary because of natural menopause and that the postmenopausal ovary appears to be an ongoing site of testosterone production.
Dietary soy has both beneficial and potentially adverse cardiovascular effects: a placebo-controlled study in men and postmenopausal women.
TLDR
In normotensive men and postmenopausal women, soy improved BP and lipids but, overall, did not improve vascular function, and the arterial functional model demonstrated no difference between groups; although again, overall function improved in both groups.
Androgen therapy in women: an Endocrine Society Clinical Practice guideline.
TLDR
Although there is evidence for short-term efficacy of testosterone in selected populations, such as surgically menopausal women, the Task Force recommends against the generalized use of testosterone by women because the indications are inadequate and evidence of safety in long-term studies is lacking.
Minireview: Aromatase and the Regulation of Estrogen Biosynthesis-Some New Perspectives.
TLDR
In postmenopausal women, as in men, estrogen is no longer solely an endocrine factor, but instead is produced in a number of extragonadal sites and acts locally at these sites in a paracrine and intracrine fashion.
Testosterone for low libido in postmenopausal women not taking estrogen.
TLDR
In postmenopausal women not receiving estrogen therapy, treatment with a patch delivering 300 microg of testosterone per day resulted in a modest but meaningful improvement in sexual function.
Summary of the recommendations on sexual dysfunctions in women.
TLDR
There is a need for more research and scientific reporting, re-assessment, and management of women's sexual dysfunction including long-term outcome studies.
Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline.
TLDR
Menopausal hormone therapy (MHT) is the most effective treatment for vasomotor symptoms and other symptoms of the climacteric and benefits may exceed risks for the majority of symptomatic postmenopausal women who are under age 60 or under 10 years since the onset of menopause.
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