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Tristetraprolin Regulates CXCL1 (KC) mRNA Stability1
mRNAs encoding proinflammatory chemokines are regulated posttranscriptionally via adenine-uridine-rich sequences (AREs) located in the 3′ untranslated region of the message, which are recognized byExpand
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Toll IL-1 Receptors Differ in Their Ability to Promote the Stabilization of Adenosine and Uridine-Rich Elements Containing mRNA1
Several ligands for Toll IL-1R (TIR) family are known to promote stabilization of a subset of short-lived mRNAs containing AU-rich elements (AREs) in their 3′ untranslated regions. It is now evidentExpand
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Myeloid Colony-Stimulating Factors as Regulators of Macrophage Polarization
The scope of functional heterogeneity in macrophages has been defined by two polarized end states known as M1 and M2, which exhibit the proinflammatory activities necessary for host defense and theExpand
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IL-17 Regulates CXCL1 mRNA Stability via an AUUUA/Tristetraprolin-Independent Sequence
IL-17 contributes to inflammatory response in part by promoting enhanced expression of chemokines, such as CXCL1, by prolonging the t1/2 of this constitutively unstable mRNA. Although IL-17 is a weakExpand
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Cell type- and stimulus-specific mechanisms for post-transcriptional control of neutrophil chemokine gene expression.
mRNAs encoding inflammatory chemokines that recruit neutrophils frequently exhibit short half-lives that serve to limit their expression under inappropriate conditions but are often prolonged toExpand
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Chemokine and chemoattractant receptor expression: post-transcriptional regulation.
The magnitude and character of the inflammatory process are determined in part via the trafficking of leukocytes into sites of injury and infection, and this process depends on proper control of theExpand
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Regulation of Chemokine mRNA Stability by Lipopolysaccharide and IL-101
IL-10 has been reported to inhibit the expression of LPS-induced proinflammatory cytokines and chemokines by altering the rate of specific mRNA decay although the molecular target(s) for its actionExpand
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TGFβ inhibits LPS-induced chemokine mRNA stabilization
: The mechanisms involved in anti-inflammatory action of transforming growth factor beta (TGFbeta) have been examined by evaluating its effect on chemokine gene expression in mouse macrophages.Expand
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Functionally Independent AU-rich Sequence Motifs Regulate KC (CXCL1) mRNA*
Certain pro-inflammatory chemokine mRNAs containing adenine/uridine-rich sequence elements (AREs) in their 3′ untranslated regions (3′-UTRs) are known to exhibit constitutive instability andExpand
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Diversity in post-transcriptional control of neutrophil chemoattractant cytokine gene expression.
Regulation of neutrophil chemokine gene expression represents an important feature in tissue inflammation. While chemokine gene transcription through the action of NFkappaB is recognized as anExpand
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