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Neurobiology of butyrylcholinesterase
TLDR
Evidence that butyrylcholinesterase has important roles in cholinergic neurotransmission and could be involved in other nervous system functions and in neurodegenerative diseases is reviewed. Expand
Cholinesterases: roles in the brain during health and disease.
TLDR
A number of new lines of evidence suggest that both cholinesterase inhibitors (ChEs) may have broader functions in the CNS than previously thought, which relate to both 'classical' esterase activities of the enzymes as well as non-classical actions unrelated to their enzymatic function. Expand
Inhibition of Human Cholinesterases by Drugs Used to Treat Alzheimer Disease
TLDR
Development of drugs targeted toward the exclusive inhibition of one or the other cholinesterase may be important for understanding the relative importance of inhibition of BuChE and AChE in the treatment of this disease. Expand
Distribution of butyrylcholinesterase in the human amygdala and hippocampal formation
TLDR
The distribution of BuChE in the normal human amygdala and hippocampal formation is studied and that of AChE is compared by using histochemical techniques to determine the importance of these enzymes in Alzheimer's disease. Expand
Butyrylcholinesterase Is Associated With &bgr;-Amyloid Plaques in the Transgenic APPSWE/PSEN1dE9 Mouse Model of Alzheimer Disease
TLDR
Histochemical analysis of Alzheimer disease brain tissues indicates that butyrylcholinesterase (BuChE) is present in A&bgr;-amyloid plaques and may play a role in AD plaque maturation, and observations suggest that BuChE is associated with a subpopulation of A& bgr; plaques. Expand
Butyrylcholinesterase-knockout reduces brain deposition of fibrillar β-amyloid in an Alzheimer mouse model
TLDR
The Knock-out of BChE in this model showed diminished fibrillar Aβ plaque deposition, more so in males than females, suggesting that lack of B ChE reduces deposition of fibrilar A β in AD and this effect may be influenced by sex. Expand
On the active site for hydrolysis of aryl amides and choline esters by human cholinesterases.
TLDR
Based on the substrate structure-activity relationships and kinetic studies, the hydrolysis of anilides and esters of choline appears to utilize the same catalytic site in BuE, and N-(2-nitrophenyl)alkylamides with six to eight carbon atoms in the acyl group represent suitable specific substrates to investigate further the function of the AAA activity of BuChE. Expand
An MRI brain atrophy and lesion index to assess the progression of structural changes in Alzheimer's disease, mild cognitive impairment, and normal aging: a follow-up study.
TLDR
The BALI rating quantified the progression of brain deficits over two years, which is associated with cognitive decline, and may be used to help summarize AD-associated structural variations. Expand
An MRI-Based Semiquantitative Index for the Evaluation of Brain Atrophy and Lesions in Alzheimer’s Disease, Mild Cognitive Impairment and Normal Aging
TLDR
The T1-based BALI helps describe brain structural variability in AD, mild cognitive impairment and normal aging. Expand
Enhancement of survival of stored dopaminergic cells and promotion of graft survival by exposure of human fetal nigral tissue to glial cell line--derived neurotrophic factor in patients with
TLDR
The results indicate that GDNF promotes survival of stored dopaminergic cells, and cells stored without GDNF had a 30.1% decrease in survival time compared with those exposed to GDNF. Expand
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