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Structural Basis of Transcription Initiation: An RNA Polymerase Holoenzyme-DNA Complex
The crystal structure of Thermus aquaticus RNA polymerase holoenzyme (α2ββ′ωσA) complexed with a fork-junction promoter DNA fragment has been determined by fitting high-resolution x-ray structures of
Structural Basis of Transcription Initiation: RNA Polymerase Holoenzyme at 4 Å Resolution
The crystal structure of the initiating form of Thermus aquaticus RNA polymerase, containing core RNA polymerase (α2ββ′ω) and the promoter specificity σ subunit, has been determined at 4 angstrom
Bacterial RNA polymerases: the wholo story.
Structure of the bacterial RNA polymerase promoter specificity sigma subunit.
TLDR
Crystal structures of each domain of the sigma subunit were determined, as well as of sigma(4) complexed with -35 element DNA, and genetic studies correctly predicted that a helix-turn-helix motif in sigma (4) recognizes the - 35 element but not the details of the protein-DNA interactions.
Bacterial sigma factors: a historical, structural, and genomic perspective.
TLDR
The key advances in σ biology are recounted, from their discovery 45 years ago to the most recent progress in understanding their structure and function at the atomic level, and both the housekeeping and alternative σs are discussed.
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