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Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.
The pathological findings in 100 patients diagnosed prospectively by a group of consultant neurologists as having idiopathic Parkinson's disease are reported, and these observations call into question current concepts of Parkinson's Disease as a single distinct morbid entity. Expand
Preliminary NINDS neuropathologic criteria for Steele‐Richardson‐Olszewski syndrome (progressive supranuclear palsy)
We present the preliminary neuropathologic criteria for progressive supranuclear palsy (PSP) as proposed at a workshop held at the National Institutes of Health, Bethesda, MD, April 24 and 25, 1993.Expand
Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia.
An increase in total iron content appears to be a response to neurodegeneration in affected basal ganglia regions in a number of movement disorders, suggesting an alteration of iron handling in the substantia nigra in PD. Expand
Validity and Reliability of the Preliminary NINDS Neuropathologic Criteria for Progressive Supranuclear Palsy and Related Disorders
It was showed that with routine sampling and staining methods, neuropathologic examination alone was not fully adequate for differentiating the disorders and a clinicopathologic diagnostic criteria to improve on the NINDS criteria is proposed. Expand
A clinicopathologic study of 100 cases of Parkinson's disease.
The clinical details of 100 cases of histologically confirmed Parkinson's disease were examined and correlated with pathologic findings, finding the general pattern of disease conformed to traditional descriptions, and the findings broaden the present clinical and pathologic spectrum of Parkinson's Disease. Expand
Oxidative DNA Damage in the Parkinsonian Brain: An Apparent Selective Increase in 8‐Hydroxyguanine Levels in Substantia Nigra
Analysis of products of oxidation and deamination of all four DNA bases in control and PD brains showed that levels of 8‐hydroxyguanine (8‐OHG) tended to be elevated and levels of 2,6‐diamino‐4‐Hydroxy‐5‐formamidopyrimidine (FAPy guanine) tendedto be decreased in PD, but the most striking difference was a rise in 8‐ OHG in PD substantia nigra. Expand
Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia
The altered GSH/GSSG ratio in the substantia nigra in Parkinson's disease is consistent with the concept of oxidative stress as a major component in the pathogenesis of nigral cell death in Parkinson’s disease. Expand
Clinicopathological investigation of vascular parkinsonism, including clinical criteria for diagnosis
New clinical criteria for a diagnosis of VP are proposed based on the clinicopathological findings of this study, and the clinical features at presentation varied according to the speed of onset and the underlying vascular pathological state. Expand
Multiple system atrophy: A review of 203 pathologically proven cases
Characteristic glial and/or neuronal cytoplasmic inclusions were identified in all cases in which they were sought, irrespective of clinical presentation, and an association of postural hypotension with intermediolateral cell column degeneration was confirmed. Expand
The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service.
The clinical and pathological diagnoses of 143 cases of parkinsonism seen by neurologists associated with the movement disorders service at The National Hospital for Neurology and Neurosurgery in London suggest that neurologists with particular expertise in the field of movement disorders may be using a method of pattern recognition for diagnosis which goes beyond that inherent in any formal set of diagnostic criteria. Expand