S. D. de Córdoba

Publications54
h-index32
Citations6,855
Highly Influential Citations230
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
TLDR
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms.
Gain-of-function mutations in complement factor B are associated with atypical hemolytic uremic syndrome
TLDR
Functional analyses demonstrated that F286L and K323E aHUS-associated BF mutations are gain-of-function mutations that result in enhanced formation of the C3bBb convertase or increased resistance to inactivation by complement regulators.
Characterization of complement factor H-related (CFHR) proteins in plasma reveals novel genetic variations of CFHR1 associated with atypical hemolytic uremic syndrome.
The factor H-related protein family (CFHR) is a group of minor plasma proteins genetically and structurally related to complement factor H (fH). Notably, deficiency of CFHR1/CFHR3 associates with…
A novel protein tyrosine phosphatase gene is mutated in progressive myoclonus epilepsy of the Lafora type (EPM2).
TLDR
The findings suggest that Lafora disease results from the mutational inactivation of a PTPase activity that may be important in the control of glycogen metabolism.
Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains
TLDR
These animals represent the first model of aHUS and provide in vivo evidence that effective plasma C3 regulation and the defective control of complement activation on renal endothelium are the critical events in the molecular pathogenesis of FH-associated aH US.
Structural and functional characterization of factor H mutations associated with atypical hemolytic uremic syndrome.
TLDR
The hypothesis that patients with aHUS carry a specific dysfunction in the protection of cellular surfaces from complement activation is supported, offering new possibilities to improve diagnosis and develop appropriate therapies.
The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity.
TLDR
A demonstration of the functional consequences of the fH-Ile(62) polymorphism provides relevant insights into the complement regulatory activities of fH that will be useful in disease prediction and future development of effective therapeutics for disorders caused by complement dysregulation.
New approaches to the treatment of dense deposit disease.
TLDR
A diagnostic and treatment algorithm for patients with dense deposit disease is presented on the basis of pathophysiology and novel therapies should be integrated into existing protocols for DDD and evaluated using an open-label Bayesian study design.
Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis
High frequency of alkaptonuria in Slovakia: evidence for the appearance of multiple mutations in HGO involving different mutational hot spots.
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