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The antiepileptic activity of JSTX-3 is mediated by N-methyl-D-aspartate receptors in human hippocampal neurons
The findings suggest that in human hippocampal neurons, the antiepileptic effect of JSTX-3 is mediated by its action on N-methyl-D-aspartate receptor.
Effects of Spider Venom Toxin PWTX-I (6-Hydroxytrypargine) on the Central Nervous System of Rats
The 6-HT was administrated by perfusion and ejection in “brain slices” of hippocampus, inducing epileptic activity after its administration; the toxin was not able to block the epileptogenic crisis observed in the chronic model of the epilepsy, suggesting that 6- HT did not block the overactive GluRs responsible for this epilepticActivity.
Bothriurus bonariensis scorpion venom activates voltage-dependent sodium channels in insect and mammalian nervous systems.
- Douglas Silva dos Santos, E. L. Carvalho, +11 authors P. M. Pinto
- Biology, MedicineChemico-biological interactions
- 25 October 2016
The results suggest that the biological activity of BBV is mostly related to a modulation of sodium channels function, and suggests that BBV may have a promising insecticidal and therapeutic potential.
Methylprednisolone as a memory enhancer in rats: Effects on aversive memory, long-term potentiation and calcium influx
- Liane S. Vargas, Rithiele Gonçalves, +13 authors P. Mello-Carpes
- Medicine, PsychologyBrain Research
- 1 September 2017
It is demonstrated that a low daily dose of methylprednisolone (MP, 5mg/kg, i.p.) administered for 10-days favors aversive memory persistence in adult rats, without any effect on the exploring behavior, locomotor activity, anxiety levels and pain perception.
Antiepileptic effect of acylpolyaminetoxin JSTX-3 on rat hippocampal CA1 neurons in vitro
The results suggest that the toxin JSTX-3 is a potent blocker of induced epileptiform activity.
The antidepressant effect of bone marrow mononuclear cell transplantation in chronic stress
- P. A. D. do Prado-Lima, Guilherme Ary Onsten, +11 authors J. daCosta
- MedicineJournal of psychopharmacology
- 25 April 2019
Findings suggest administration of BMMC in rats subjected to CS restores sucrose preference, resolves inflammation in both the peripheral and central nervous system, as well as diminishes DNA damage.
Measurement of the Compound and Extracellular Action Potential of the Spinal Cord: Technical Report and Experimental Applications
The compound and extracellular action potential could be generated in both experiments indicating that the functional analysis of spinal cord neurons can be assessed by in vitro stimulation of the spinal cord tissue or its slice.
Bone marrow mononuclear cell transplant prevents rat depression and modulates inflammatory and neurogenic molecules
- Zaquer Suzana Munhoz Costa-Ferro, Pedro Antônio Prado-Lima, +11 authors J. Costa
- MedicineProgress in Neuro-Psychopharmacology and…
- 9 October 2021
Bone marrow mononuclear cell transplantation prevents the development of depression and anxiety-like behavior triggered by chronic mild stress, and could prevent increased HMGB-1 and IL-1β expression in the hippocampus and increased BDNFexpression in the same tissue.
Neurotoxic and convulsant effects induced by Jack Bean Ureases on the Mammalian Nervous System.
- Carlos G.M. Almeida, Kiyo Costa-Higuchi, +14 authors C. Carlini
- Chemistry, MedicineToxicology
- 22 February 2021
Understanding the neurotoxic mode of action of C. ensiformis ureases could help to unveil the so far underappreciated relevance of these toxins in diseases caused by urease-producing microorganisms, in which the human central nervous system is affected.
Toxicity Testing in Vitro and Biocompatibility Scaffold for Transplantation of Stem Cells in Spinal Cord Injury
PLGA/PPy polymer has conductivity expected for semiconductors and structural heterogeneity, without any type of cell toxicity in periods and is safe to be used as a scaffold in the TRM model because it does not cause any functional, structural, or inflammatory change.