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Use of granulocyte-colony stimulating factor during acute myocardial infarction to enhance bone marrow stem cell mobilization in humans: clinical and angiographic safety profile.
TLDR
G-CSF administration in acute MI patients was feasible and did not lead to any clinical or angiographic adverse events and resulted in CD34(+) and CD34 (+)AC133(+)VEGFR2(+) cell mobilization.
Oxidative stress during myocardial ischaemia and heart failure.
TLDR
It is possible that the immunological response to heart failure results in endothelial and myocyte dysfunction through oxidative stress mediated apoptosis, and clarification of these mechanisms may lead to novel therapeutic strategies.
Oxygen free radicals and myocardial damage: protective role of thiol-containing agents.
TLDR
The cardioprotective role of thiol-containing agents is reviewed and N-acetylcysteine increases, in a dose-dependent manner, the myocardial glutathione content and provides an important degree of protection against ischemia and reperfusion.
Oxygen-mediated myocardial damage during ischaemia and reperfusion: role of the cellular defences against oxygen toxicity.
TLDR
Data indicate that severe ischaemia induces a reduction of the protective mechanisms against oxygen toxicity.
Apoptosis of Endothelial Cells Precedes Myocyte Cell Apoptosis in Ischemia/Reperfusion Injury
TLDR
The radial spread of apoptosis to surrounding cardiac myocytes suggests that reperfusion induces the release of soluble pro-apoptotic mediators from endothelial cells that promote myocyte apoptosis.
5-Year Outcomes After Transcatheter Aortic Valve Implantation With CoreValve Prosthesis.
TLDR
TAVI with the currently adopted CoreValve generation was associated with sustained clinical outcomes up to 5-year follow-up, with a low rate (1.4%) of significant prosthetic valve degeneration.
Direct transcatheter aortic valve implantation with self-expandable bioprosthesis: feasibility and safety.
TLDR
Compared to T AVI with pre-dilation, direct TAVI is feasible regardless of the presence of bulky calcified aortic valve and the valve size implanted, and safety at 30 days was similar in two groups.
The role of glutathione status in the protection against ischaemic and reperfusion damage: effects of N-acetyl cysteine.
TLDR
The role of glutathione status in the protection against ischaemic and reperfusion damage by treating the isolated rabbit hearts with N-acetylcysteine is evaluated, finding a 38% increase in tissue content of GSH with no major changes of GSSG or protein SH.
Myocardial recovery during post-ischaemic reperfusion: effects of nifedipine, calcium and magnesium.
TLDR
Reperfusion with high magnesium reduced the mitochondrial calcium overload and maintained the mitochondrial ATP-producing capacity but failed to modify the increase of tissue calcium and of diastolic pressure, suggesting that the conditions of reperfusion may influence the capacity of myocardial recovery.
Occurrence of oxidative stress during reperfusion of the human heart.
TLDR
Data suggest for the first time that, depending on the severity of the ischemic period, oxidative stress occurs during reperfusion of patients with coronary artery disease who are subjected to heart surgery and that it may be linked with a delay in postoperative recovery of cardiac function.
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