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Metabolism and disposition of methylphenidate-14C: studies in man and animals.
MEPH- 14 C·HCl was found to be extensively metabolized in man, dog, rat and mouse, and pronounced species differences in the metabolism of the drug were found.
Effects of physical stress on the disposition of drugs eliminated by the liver in man.
Data indicate that liver plasma flow is the major determinant of the disposition of rapidly excreted drugs like ICG and antipyrine, and significant changes in the initial plasma concentration, the pattern of tissue distribution and the initial rate of plasma disappearance of AP are attributable to the stresses of heat, exercise and fluid deprivation.
Studies of the metabolism of dapsone in man and experimental animals: formation of N-hydroxy metabolites.
A number of metabolites and derivatives of DDS were synthesized and tested for their ability to produce methemoglobin and a new metabolite—the monohydroxylamine of 4-acetylamino-4' aminodiphenylsulfone—was also identified.
Review of the toxicity of long-term phosgene exposure.
  • S. Cucinell
  • Medicine, Environmental Science
    Archives of environmental health
  • 1974
An estimate of the phosgene concentration that would have no deleterious effects on persons working regularly with the agent and on people living in the surrounding areas was developed. After
Mauna Kea III: Metabolic Effects of Dietary Carbohydrate Supplementation During Exercise at 4100 M Altitude.
The study results confirm and extend previous studies suggesting that carbohydrate supplementation is beneficial during strenuous exercise at high altitude.
Drug interactions in man
The ability of a drug to stimulate its own metabolism or the metabolism of another drug appears to have important implications in clinical pharmacologic studies, as weU as to the problem of drug therapy in man.
Dose-dependence of drug plasma level decline in dogs.
It has been found that for several drugs the rate of disappearance from plasma is dependent on the dose, and the effect of dose has been interpreted as a special case of inhibition, the self-inhibition of metabolism of a drug.
Antidiuretic hormone responses to eucapnic and hypocapnic hypoxia in humans.
Urinary excretion rate of antidiuretic hormone was studied in male volunteers in response to hypobaric hypoxia and increased UADHV in asymptomatic subjects may be a result of the concomitant decrease in plasma volume, both of which appeared to be eliminated by CO2 supplementation.
Effects of 7 successive days of unaccustomed prolonged exercise on aerobic performance and tissue damage in fitness joggers.
Soreness was accompanied by chronic elevations in serum levels of myoglobin, creatine kinase, lactic dehydrogenase, aminoaspartate, and the isoenzymes CK-MB and LD1,2, suggestive of footstrike hemolysis.