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Antimalarial drug discovery: efficacy models for compound screening
- D. Fidock, P. Rosenthal, S. Croft, R. Brun, S. Nwaka
- Biology, MedicineNature Reviews Drug Discovery
- 1 June 2004
Different in vitro and in vivo screens for antimalarial drug discovery are suggested and a streamlined process for evaluating new compounds on the path from drug discovery to development is recommended.
Leishmaniasis--current chemotherapy and recent advances in the search for novel drugs.
Drug Resistance in Leishmaniasis
It is essential that there be a strategy to prevent the emergence of resistance to new drugs; combination therapy, monitoring of therapy, and improved diagnostics could play an essential role in this strategy.
Current scenario of drug development for leishmaniasis.
- S. Croft, K. Seifert, V. Yardley
- Biology, ChemistryThe Indian journal of medical research
- 1 March 2006
Alternative and potentially cheaper formulations of amphotericin B, alklyphosphocholines other than miltefosine and improved formulations of paromomycin for CL have been identified and drugs or compounds that have demonstrated activity in experimental rodent models of infection are identified.
Visceral leishmaniasis: current status of control, diagnosis, and treatment, and a proposed research and development agenda.
Management of trypanosomiasis and leishmaniasis
Clinical studies with benznidazole, a drug previously recommended only for acute stage treatment, are close to completion to determine the effectiveness in the treatment of early chronic and indeterminate Chagas disease.
Kinetoplastids: related protozoan pathogens, different diseases.
Kinetoplastids are a group of flagellated protozoans that include the species Trypanosoma and Leishmania, which are human pathogens with devastating health and economic effects. The sequencing of the…
Leishmaniasis: new approaches to disease control
Leishmaniasis is one of the major infectious diseases affecting the poorest regions of the world, but new developments in diagnosis, treatment, and control offer some fresh hope
In Vitro and In Vivo Interactions between Miltefosine and Other Antileishmanial Drugs
Different interactions were found in vivo, where the highest potentiation of miltefosine activity was achieved with amphotericin B (activity enhancement index [AEI] of up to 11.3).
Natural products as antiparasitic drugs
This review shows that many novel lead structures in natural products, including plant-derived alkaloids, terpenes and phenolics, have severe chemico-physical drawbacks such as poor solubility and here, innovative drug formulations and carrier systems might help.