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The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development
Development of the Drosophila CNS midline cells is dependent upon the function of the single-minded (sim) gene. Sequence analysis shows that sim is a member of the basic-helix-loop-helix class ofExpand
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Control of cell lineage-specific development and transcription by bHLH-PAS proteins.
  • S. Crews
  • Biology, Medicine
  • Genes & development
  • 1 March 1998
The basic–helix–loop–helix-PAS (bHLH–PAS) proteins comprise a prominent class of transcriptional regulators that control a variety of developmental and physiological events including neurogenesis,Expand
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Molecular genetics of the single-minded locus: A gene involved in the development of the Drosophila nervous system
The embryonic neuroepithelium of Drosophila gives rise to the central nervous system. We have studied the mutant phenotype and expression of a gene, single-minded (sim), which is involved inExpand
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The Drosophila tango gene encodes a bHLH-PAS protein that is orthologous to mammalian Arnt and controls CNS midline and tracheal development.
The Drosophila single-minded and trachealess bHLH-PAS genes control transcription and development of the CNS midline cell lineage and tracheal tubules, respectively. We show that Single-minded andExpand
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Functional Interactions between DrosophilabHLH/PAS, Sox, and POU Transcription Factors Regulate CNS Midline Expression of the slit Gene
During Drosophila embryogenesis the CNS midline cells have organizing activities that are required for proper elaboration of the axon scaffold and differentiation of neighboring neuroectodermal andExpand
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The single-minded gene of Drosophila is required for the expression of genes important for the development of CNS midline cells
The single-minded (sim) gene of Drosophila encodes a nuclear protein that plays a critical role in the development of the neurons, glia, and other nonneuronal cells that lie along the midline of theExpand
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The spineless-aristapedia and tango bHLH-PAS proteins interact to control antennal and tarsal development in Drosophila.
The Drosophila spineless (ss) gene encodes a basic-helix-loop-helix-PAS transcription factor that is required for proper specification of distal antennal identity, establishment of the tarsal regionsExpand
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The Drosophila abrupt gene encodes a BTB-zinc finger regulatory protein that controls the specificity of neuromuscular connections.
Motor axons make synaptic connections with specific muscles, and this specificity unfolds during development as motoneuron growth cones make specific pathway choices and ultimately recognize andExpand
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The Drosophila single-minded gene encodes a nuclear protein with sequence similarity to the per gene product
Mutations in the single-minded (sim) gene of Drosophila result in the loss of the precursor cells giving rise to the midline cells of the embryonic central nervous system. We have examined theExpand
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