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The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development
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Control of cell lineage-specific development and transcription by bHLH-PAS proteins.
  • S. Crews
  • Biology
    Genes & development
  • 1 March 1998
TLDR
How bHLH–PAS proteins control lineage-specific gene transcription and development of the Drosophila CNS midline cells and respiratory system is described, and the evolutionary implications of the b HLH-PAS/ Arnt regulatory cassette are discussed.
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"Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome.".
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Molecular genetics of the single-minded locus: A gene involved in the development of the Drosophila nervous system
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A single VH gene segment encodes the immune response to phosphorylcholine: Somatic mutation is correlated with the class of the antibody
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The Drosophila tango gene encodes a bHLH-PAS protein that is orthologous to mammalian Arnt and controls CNS midline and tracheal development.
TLDR
Both cell culture and in vivo studies show that a DNA enhancer element acts as a binding site for both Single-minded::tango and Trachealess::Tango heterodimers and functions in controlling CNS midline and tracheal transcription.
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CNS midline enhancers of the Drosophila slit and Toll genes
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Functional Interactions between DrosophilabHLH/PAS, Sox, and POU Transcription Factors Regulate CNS Midline Expression of the slit Gene
TLDR
It is shown here that Fish-hook (Fish), a Sox HMG domain protein, and Drifter (Dfr), a POU domainprotein, act in concert with Single-minded to control midline gene expression, indicating that mid line gene regulation involves the coordinate functions of three distinct types of transcription factors.
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The single-minded gene of Drosophila is required for the expression of genes important for the development of CNS midline cells
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The Drosophila abrupt gene encodes a BTB-zinc finger regulatory protein that controls the specificity of neuromuscular connections.
TLDR
The Drosophila clueless mutation, identified previously in a genetic screen for mutations that disrupt motoneuron guidance and connectivity, is shown to be allelic to abrupt, suggesting that abrupt controls the muscle expression of molecules required for correct mot oneuron targeting, as well as molecules necessary for correct muscle attachments.
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