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Gain of chromosome arm 17q and adverse outcome in patients with neuroblastoma.
BACKGROUND Gain of genetic material from chromosome arm 17q (gain of segment 17q21-qter) is the most frequent cytogenetic abnormality of neuroblastoma cells. This gain has been associated withExpand
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Ifosfamide-containing chemotherapy in Ewing's sarcoma: The Second United Kingdom Children's Cancer Study Group and the Medical Research Council Ewing's Tumor Study.
PURPOSE To investigate the possibility that the substitution of ifosfamide for cyclophosphamide therapy for Ewing's sarcoma will improve survival over that seen in the first United Kingdom Children'sExpand
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Gain of chromosome arm 17q predicts unfavourable outcome in neuroblastoma patients. U.K. Children's Cancer Study Group and the U.K. Cancer Cytogenetics Group.
Gain of chromosome arm 17q has recently been reported in neuroblastoma tumours. We analysed 17q status in relation to other known prognostic features and clinical outcome in a series of 45 tumours.Expand
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Long-term results from the first UKCCSG Ewing's tumour study (ET-1)
The aim of this study was to evaluate multimodal chemotherapy and radiotherapy in patients with Ewing's sarcoma. 142 (74 male, 68 female) patients were entered into the ET-1 study between 1978 andExpand
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Comprehensive genetic and histopathologic study reveals three types of neuroblastoma tumors.
PURPOSE To determine the relationship between multiple genetic features, tumor morphology, and prognosis in neuroblastoma. PATIENTS AND METHODS The genetic alterations and morphologic features thatExpand
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Breakpoint position on 17q identifies the most aggressive neuroblastoma tumors
Gain of chromosome arm 17q is a powerful prognostic factor in neuroblastoma, and the distribution of 17q breakpoints suggests that the dosage of one or more genes in 17q22–23 to 17qter is criticalExpand
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The epidemiology of assault across the West Midlands
Objectives: The purpose of this study is to look at accident and emergency (A&E) attendances and admissions after assault in the West Midlands NHS region across a wide range of acute units. Methods:Expand
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An unusual source for an outbreak of methicillin-resistant Staphylococcus aureus on an intensive therapy unit.
During a four-month period, six patients on an intensive therapy unit became colonized or infected with methicillin-resistant Staphylococcus aureus (MRSA). Four of these patients were colonized byExpand
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Results of the United Kingdom Children's Cancer Study Group first Wilms' Tumor Study.
PURPOSE The first United Kingdom Children's Cancer Study Group (UKCCSG) Wilms' Tumor Trial (UKW1) applied treatment regimens stratified by stage and histology in accordance with National Wilms' TumorExpand
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Treatment of advanced stage T cell lymphoblastic lymphoma: results of the United Kingdom Children's Cancer Study Group (UKCCSG) protocol 8503
Summary. Ninety‐five unselected patients with stage III and IV T cell lymphoblastic lymphoma were treated according to the United Kingdom Childrens Cancer Study Group protocol 8503. This was aExpand
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