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Cloning of Two Human Thyroid cDNAs Encoding New Members of the NADPH Oxidase Family*
Two cDNAs encoding NADPH oxidases and constituting the thyroid H2O2 generating system have been cloned. The strategy of cloning was based on the functional similarities between H2O2 generation inExpand
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A molecular dissection of the glycoprotein hormone receptors.
In glycoprotein hormone receptors, a subfamily of rhodopsin-like G protein-coupled receptors, the recognition and activation steps are carried out by separate domains of the proteins. Specificity ofExpand
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  • Open Access
Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity
The monomeric model of rhodopsin‐like G protein‐coupled receptors (GPCRs) has progressively yielded the floor to the concept of GPCRs being oligo(di)mers, but the functional correlates ofExpand
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  • Open Access
Ovarian hyperstimulation syndrome due to a mutation in the follicle-stimulating hormone receptor.
The overproduction of endogenous chorionic gonadotropin during pregnancy has been associated with spontaneous ovarian hyperstimulation syndrome. Yet the syndrome has been observed in women withExpand
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Identification and characterization of an endogenous chemotactic ligand specific for FPRL2
Chemotaxis of dendritic cells (DCs) and monocytes is a key step in the initiation of an adequate immune response. Formyl peptide receptor (FPR) and FPR-like receptor (FPRL)1, two G protein–coupledExpand
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  • Open Access
Glycoprotein hormone receptors: determinants in leucine‐rich repeats responsible for ligand specificity
Glycoprotein hormone receptors [thyrotropin (TSHr), luteinizing hormone/chorionic gonadotropin (LH/CGr), follicle stimulating hormone (FSHr)] are rhodopsin‐like G protein‐coupled receptors with aExpand
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Activation of the cAMP pathway by the TSH receptor involves switching of the ectodomain from a tethered inverse agonist to an agonist.
Several lines of evidence indicate that constraining intramolecular interactions between transmembrane domains are required to maintain G protein-coupled receptors in an inactive conformation in theExpand
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Prediction of severity of symptoms in iatrogenic ovarian hyperstimulation syndrome by follicle-stimulating hormone receptor Ser680Asn polymorphism.
The ovarian hyperstimulation syndrome (OHSS) is a potentially life-threatening complication of ovarian stimulation treatments for in vitro fertilization (i.v.f.). Recently, three different mutationsExpand
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  • Open Access
Allosteric Modulation of Binding Properties between Units of Chemokine Receptor Homo- and Hetero-Oligomers
We have demonstrated previously that the chemokine receptors CCR2 and CCR5 form homo- and heterodimers and that dimers can only bind a single chemokine molecule with high affinity. We provide hereExpand
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  • Open Access
Characterization of a novel loss of function mutation of PAX8 in a familial case of congenital hypothyroidism with in-place, normal-sized thyroid.
Thyroid dysgenesis is the most common cause of congenital hypothyroidism, a relatively frequent disease affecting 1 in 3000-4000 newborns. Whereas most cases are sporadic, mutations in transcriptionExpand
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