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Isolation of a novel species of flavivirus and a new strain of Culex flavivirus (Flaviviridae) from a natural mosquito population in Uganda
TLDR
The discovery, isolation and characterization of two novel ‘insect-only’ flaviviruses from Entebbe, Uganda: a novel lineage tentatively designated Nakiwogo virus (NAKV) and a new strain of CxFV. Expand
Isolation of a new strain of the flavivirus cell fusing agent virus in a natural mosquito population from Puerto Rico.
TLDR
Results from viral screening, and cell culture and molecular identification of the infected mosquitoes are presented, supporting previous suggestions of the existence of a large number of unsampled flaviviruses and elucidating the mechanism by which flaviviral sequences may have integrated into mosquito genomes. Expand
Phylogenetic analysis and temporal diversification of mosquitoes (Diptera: Culicidae) based on nuclear genes and morphology
TLDR
The results support the notion of rapid radiations early in the diversification of mosquitoes, and suggest the need for additional taxonomic sampling. Expand
Structure and functionality in flavivirus NS-proteins: Perspectives for drug design
TLDR
Structural and functional aspects emerging from the characterization of two main components (NS3 and NS5 proteins) of the flavivirus replication complex are reviewed to shed light on the design and development of antiviral drug leads. Expand
Sequences of flavivirus-related RNA viruses persist in DNA form integrated in the genome of Aedes spp. mosquitoes.
TLDR
These flavivirus-related integrated DNA sequences were detected in laboratory-bred and wild Aedes albopictus and Aedes aegypti mosquitoes, demonstrating that their discovery is not an artefact resulting from the manipulation of mosquito cell lines, since they exist under natural conditions. Expand
Molecular phylogeny and evolutionary timescale for the family of mammalian herpesviruses.
TLDR
A detailed phylogenetic analysis for mammalian members of the family Herpesviridae, based on molecular sequences is reported, finding that major sublineages within subfamilies were probably generated before the mammalian radiation of 80 to 60 million years ago, and that speciations within sub lineages took place in the last 80 million years, probably with a major component of cospeciation with host lineages. Expand
Novel Virus Discovery and Genome Reconstruction from Field RNA Samples Reveals Highly Divergent Viruses in Dipteran Hosts
TLDR
It is clear that viral transmission and maintenance cycles in nature are likely to be significantly more complex and taxonomically diverse than previously expected. Expand
Molecular phylogeny of the alphaherpesvirinae subfamily and a proposed evolutionary timescale.
TLDR
It was estimated that the two mammalian alphaherpesvirus groups diverged around the period of the mammalian radiation, and that alphaherpeviral genome sequences have evolved faster than those of mammals by a factor of one to two orders of magnitude. Expand
A multigene analysis of the phylogenetic relationships among the flaviviruses (Family: Flaviviridae) and the evolution of vector transmission
TLDR
This most comprehensive phylogenetic study to date, involving maximum likelihood analyses of the NS3 and NS5 genes and the entire genome sequences available at present, shows that (i) the NS5 gene contains insufficient phylogenetic signal to choose between competing topological hypotheses, and (ii) the whole genome data indicate that the mosquito-borne flaviviruses represent an outgroup to the remaining flavivirus. Expand
Punique virus, a novel phlebovirus, related to sandfly fever Naples virus, isolated from sandflies collected in Tunisia.
TLDR
Genetic and phylogenetic characterization based on sequences in the three genomic segments showed that it was a novel virus distinct from other recognized members of the species, provisionally named Punique virus. Expand
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