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Apc tumor suppressor gene is the "zonation-keeper" of mouse liver.
The molecular mechanisms by which liver genes are differentially expressed along a portocentral axis, allowing for metabolic zonation, are poorly understood. We provide here compelling evidence thatExpand
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Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas.
Although inappropriate activation of the Wnt/beta-catenin pathway has been implicated in the development of hepatocellular carcinoma (HCC), the role of this signaling in liver carcinogenesis remainsExpand
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Crypt-restricted proliferation and commitment to the Paneth cell lineage following Apc loss in the mouse intestine
Loss of Apc appears to be one of the major events initiating colorectal cancer. However, the first events responsible for this initiation process are not well defined and the ways in which differentExpand
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Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers
Murine models of familial adenomatous polyposis harbor a germinal heterozygous mutation on Apc tumor suppressor gene. They are valuable tools for studying intestinal carcinogenesis, as most humanExpand
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The H19 locus acts in vivo as a tumor suppressor
The H19 locus belongs to a cluster of imprinted genes that is linked to the human Beckwith-Wiedemann syndrome. The expression of H19 and its closely associated IGF2 gene is frequently deregulated inExpand
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T‐cell factor 4 and β‐catenin chromatin occupancies pattern zonal liver metabolism in mice
β‐catenin signaling can be both a physiological and oncogenic pathway in the liver. It controls compartmentalized gene expression, allowing the liver to ensure its essential metabolic function. It isExpand
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Stabilization of β‐catenin affects mouse embryonic liver growth and hepatoblast fate
During hepatogenesis, after the liver has budded out of the endoderm, the hepatoblasts quickly expand and differentiate into either hepatocytes or biliary cells, the latter of which arise only withinExpand
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Oncogenic β-catenin triggers an inflammatory response that determines the aggressiveness of hepatocellular carcinoma in mice.
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Its pathogenesis is frequently linked to liver inflammation. Gain-of-function mutations in the geneExpand
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Identification of the IFITM family as a new molecular marker in human colorectal tumors.
We analyzed the expression profiles of intestinal adenomas from a new murine familial adenomatous polyposis model (Apc(delta14/+)) using suppression subtractive hybridization to identify novelExpand
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Wnt/beta-catenin pathway in hepatocellular carcinoma pathogenesis and liver physiology.
The Wnt/beta-catenin pathway is a key developmental pathway for which alterations have been described in various human cancers. The aberrant activation of this pathway is a major event in humanExpand
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