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Oxidized LDL-induced injury and apoptosis in atherosclerosis. Potential roles for oxysterols.
TLDR
Cell injury and death appear to play multiple roles in lesion development and the toxic lipid constituents of oxidized lipoproteins, including a variety of oxysterols, are candidates for the in vivo effectors of this cytotoxicity. Expand
Protein Kinase C&dgr;–Dependent Phosphorylation of Syndecan-4 Regulates Cell Migration
TLDR
The data suggested that generalized activation of PKC&dgr; by lysoPC initiated a cascade of events, including phosphorylation of syndecan-4, displacement and decreased activity ofPKC&agr;, binding of &agR;-actinin to syndECan- 4, and disruption of the time- and site-specific regulation of focal adhesion complex assembly and disassembly required for normal cell migration. Expand
In vitro cell injury by oxidized low density lipoprotein involves lipid hydroperoxide-induced formation of alkoxyl, lipid, and peroxyl radicals.
TLDR
Cell death was postulated to occur due to lipid peroxidation via a sequence involving lipid hydroperoxide-induced, iron-mediated formation of alkoxyl, lipid, and peroxyl radicals, consistent with current theories linking lipoprotein oxidation to atherosclerosis. Expand
Elucidation of a TRPC6-TRPC5 channel cascade that restricts endothelial cell movement.
TLDR
A novel mechanism for opening TRPC channels in which TRPC6 activation initiates a cascade resulting in TRPC5 translocation, which could adversely impact on EC healing in atherosclerotic arteries where lysoPC is abundant. Expand
Isolation and characterization of two distinct forms of liver fatty acid binding protein from the rat.
TLDR
It is proposed that these two distinct forms of rat L-FABP were structural conformers based on two alternative folding pathways that may result from post-translational modification or bound ligand. Expand
Leukocytes utilize myeloperoxidase-generated nitrating intermediates as physiological catalysts for the generation of biologically active oxidized lipids and sterols in serum.
TLDR
Results suggest that phagocytes may employ MPO-generated reactive nitrogen intermediates as a physiological pathway for initiating lipid peroxidation and forming biologically active lipid and sterol oxidation products in vivo. Expand
Roles of multiple oxidized LDL lipids in cellular injury: dominance of 7 beta-hydroperoxycholesterol.
TLDR
The high relative toxicity of 7 beta-hydroperoxycholesterol, the level of its accumulation on oxidized LDL, and its mechanism of action similar to oxidized HDL suggest that it is the compound predominantly responsible for oxidized cholesterol induced cytotoxicity. Expand
Lysophosphatidylcholine Inhibits Endothelial Cell Migration by Increasing Intracellular Calcium and Activating Calpain
TLDR
Endothelial cell (EC) migration, essential for reestablishing arterial integrity after vascular injury, is inhibited by oxidized LDL and lysophosphatidylcholine that are present in the arterial wall and the hypothesis that a mechanism responsible for lysoPC-induced inhibition is increased intracellular free calcium concentration was tested. Expand
Cholesterol interaction with recombinant human sterol carrier protein-2
TLDR
The data suggest that SCP-2 binds sterols with affinity consistent with a lipid transfer protein that may act either as an aqueous carrier or at a membrane surface to enhance sterol desorption. Expand
Synthetic smooth muscle cell phenotype is associated with increased nicotinamide adenine dinucleotide phosphate oxidase activity: effect on collagen secretion.
TLDR
In SMCs, the synthetic phenotype is associated with increased NADPH oxidase activity and elevated superoxide production in response to an oxidative stress, which leads to increased collagen production. Expand
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