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Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to improve the understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions. Expand
The complete genome sequence of Mycobacterium bovis
The genome sequence offers major insight on the evolution, host preference, and pathobiology of M. bovis, implying that differential gene expression may be the key to the host tropisms of human and bovine bacilli. Expand
Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis
Substitution of a limited number of highly conserved aminoacids encoded by the rpoB gene appears to be the molecular mechanism responsible for "single step" high-level resistance to rifampicin in M tuberculosis, a marker of multidrug-resistant tuberculosis. Expand
A new evolutionary scenario for the Mycobacterium tuberculosis complex
The distribution of 20 variable regions resulting from insertion-deletion events in the genomes of the tubercle bacilli has been evaluated and contradict the often-presented hypothesis that M. tuberculosis, the etiological agent of human tuberculosis evolved from M. bovis, the agent of bovine disease. Expand
Sequences Human Induced Pluripotent Stem Cells Free of Vector and Transgene
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The catalase—peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis
A single M. tuberculosis gene, katG, encoding both catalase and peroxidase, restored sensitivity to INH in a resistant mutant of Mycobacterium smegmatis, and conferred INH susceptibility in some strains of Escherichia coli. Expand
Massive gene decay in the leprosy bacillus
Comparing the 3.27-megabase genome sequence of an armadillo-derived Indian isolate of the leprosy bacillus with that of Mycobacterium tuberculosis provides clear explanations for these properties and reveals an extreme case of reductive evolution. Expand
Identification of variable regions in the genomes of tubercle bacilli using bacterial artificial chromosome arrays
Comparisons of the BAC libraries of Mycobacterium tuberculosis and the vaccine strain and the complete genome sequence of M. bovis BCG uncovered a third class of deletions consisting of two M. tuberculosis H37Rv loci, RvD1 and RVD2, deleted from the genome relative to M.bovis. Expand
Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti
A genetic lesion is described that contributes to safety and opens new avenues for vaccine development and resulted in a marked change in colonial morphology towards that of virulent tubercle bacilli. Expand
Genome plasticity of BCG and impact on vaccine efficacy
The combined findings suggest that early BCG vaccines may even be superior to the later ones that are more widely used, and that further amplification of the DU2 region is ongoing, even within vaccine preparations used to immunize humans. Expand