• Publications
  • Influence
Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
Stress can alter immunological, neurochemical and endocrinological functions, but its role in cancer progression is not well understood. Here, we show that chronic behavioral stress results in higherExpand
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A Video Game Improves Behavioral Outcomes in Adolescents and Young Adults With Cancer: A Randomized Trial
OBJECTIVE. Suboptimal adherence to self-administered medications is a common problem. The purpose of this study was to determine the effectiveness of a video-game intervention for improving adherenceExpand
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Reciprocal regulation of the neural and innate immune systems
Innate immune responses are regulated by microorganisms and cell death, as well as by a third class of stress signal from the nervous and endocrine systems. The innate immune system also feeds back,Expand
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A Functional Genomic Fingerprint of Chronic Stress in Humans: Blunted Glucocorticoid and Increased NF-κB Signaling
BACKGROUND Chronic stressors are known to increase vulnerability to medical illness, but the mechanisms underlying this phenomenon are poorly understood. METHODS To identify transcriptional controlExpand
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The influence of bio-behavioural factors on tumour biology: pathways and mechanisms
Epidemiological studies indicate that stress, chronic depression and lack of social support might serve as risk factors for cancer development and progression. Recent cellular and molecular studiesExpand
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Inflammation and behavioral symptoms after breast cancer treatment: do fatigue, depression, and sleep disturbance share a common underlying mechanism?
PURPOSE Fatigue, depression, and sleep disturbance are common adverse effects of cancer treatment and frequently co-occur. However, the possibility that inflammatory processes may underlie thisExpand
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Selective alteration of personality and social behavior by serotonergic intervention.
OBJECTIVE The authors sought to test the causal hypothesis that serotonergic function modulates aspects of the normal spectrum of individual differences in affective experience and social behavior inExpand
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Stress Hormone–Mediated Invasion of Ovarian Cancer Cells
Purpose: There is growing evidence that stress and other behavioral factors may affect cancer progression and patient survival. The underlying mechanisms for this association are poorly understood.Expand
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Molecular Pathways: Beta-Adrenergic Signaling in Cancer
  • S. Cole, A. Sood
  • Biology, Medicine
  • Clinical Cancer Research
  • 20 December 2011
Beta-adrenergic signaling has been found to regulate multiple cellular processes that contribute to the initiation and progression of cancer, including inflammation, angiogenesis, apoptosis/anoikis,Expand
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Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via β-adrenergic induction of myelopoiesis
  • N. Powell, E. Sloan, +7 authors S. Cole
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 23 September 2013
Significance Chronic exposure to adverse social environments is associated with increased risk of disease, and stress-related increases in the expression of proinflammatory genes appear to contributeExpand
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