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Meta-analyses of genetic studies on major depressive disorder
The genetic basis of major depressive disorder (MDD) has been investigated extensively, but the identification of MDD genes has been hampered by conflicting results from underpowered studies. WeExpand
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Reduced Reward Learning Predicts Outcome in Major Depressive Disorder
BACKGROUND Reduced reward learning might contribute to the onset and maintenance of major depressive disorder (MDD). In particular, the inability to utilize rewards to guide behavior is hypothesizedExpand
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The neuroactive potential of the human gut microbiota in quality of life and depression
The relationship between gut microbial metabolism and mental health is one of the most intriguing and controversial topics in microbiome research. Bidirectional microbiota–gut–brain communication hasExpand
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Glucocorticoid Receptor Gene-Based SNP Analysis in Patients with Recurrent Major Depression
Dysregulation of the hypothalamic-pituitary-adrenal axis, one of the stress-response systems, is one of the key neurobiological features of major depression (MDD). Data supporting the notion thatExpand
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Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder.
Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage. The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD genome scan data sets in anExpand
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The dopamine D4 receptor gene 48-base-pair-repeat polymorphism and mood disorders: A meta-analysis
BACKGROUND We conducted a meta-analysis to re-evaluate the role of the dopamine D4 receptor gene 48-base-pair- repeat (DRD4) polymorphism in mood disorders. METHODS DRD4 allele frequencies wereExpand
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Relationship between P-glycoprotein and second-generation antipsychotics.
The membrane transport protein P-glycoprotein (P-gp) is an interesting candidate for individual differences in response to antipsychotics. To present an overview of the current knowledge of P-gp andExpand
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A biopsychosocial model as a guide for psychoeducation and treatment of depression
Effective treatment of severe or chronic unipolar depression requires the combination of pharmacological and psychotherapeutic interventions, and demands a theoretical paradigm integrating biologicalExpand
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Non-Syndromic Deafness Associated with a Mutation and a Polymorphism in the Mitochondrial 12S Ribosomal RNA Gene in a Large Zairean Pedigree
Hereditary non-syndromic deafness has been associated with a point mutation in the mitochondrial 12S rRNA gene. We present data from deaf individuals in 12 nuclear families originating from a smallExpand
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Investigating the influence of maternal cortisol and emotional state during pregnancy on the DNA methylation status of the glucocorticoid receptor gene (NR3C1) promoter region in cord blood.
BACKGROUND The methylation status of the human glucocorticoid receptor gene NR3C1 in newborns has been reported to be sensitive to prenatal maternal mood. This study investigates both the associationExpand
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