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Overview of structure and function of mammalian cilia.
Cilia are membrane-bounded, centriole-derived projections from the cell surface that contain a microtubule cytoskeleton, the ciliary axoneme, surrounded by a ciliary membrane. Axonemes inExpand
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The primary cilium at a glance
The primary cilium, which was first so named by Sergei Sorokin ([Sorokin, 1968][1]), is a solitary organelle that emanates from the cell surface of most mammalian cell types during growth arrest.Expand
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PDGFRalphaalpha signaling is regulated through the primary cilium in fibroblasts.
Recent findings show that cilia are sensory organelles that display specific receptors and ion channels, which transmit signals from the extracellular environment via the cilium to the cell toExpand
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PDGFRαα Signaling Is Regulated through the Primary Cilium in Fibroblasts
Summary Recent findings show that cilia are sensory organelles that display specific receptors and ion channels, which transmit signals from the extracellular environment via the cilium to the cellExpand
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TGF-β signaling is associated with endocytosis at the pocket region of the primary cilium.
Transforming growth factor β (TGF-β) signaling is regulated by clathrin-dependent endocytosis (CDE) for the control of cellular processes during development and in tissue homeostasis. The primaryExpand
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Assembly of primary cilia
Primary cilia are microtubule‐based, hair‐like sensory organelles present on the surface of most growth‐arrested cells in our body. Recent research has demonstrated a crucial role for primary ciliaExpand
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Inhibition of protein phosphatase 2A induces serine/threonine phosphorylation, subcellular redistribution, and functional inhibition of STAT3.
Signal transducers and activators of transcription (STATs) are rapidly phosphorylated on tyrosine residues in response to cytokine and growth factor stimulation of cell surface receptors. STATsExpand
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Primary cilia and coordination of receptor tyrosine kinase (RTK) signalling
Primary cilia are microtubule‐based sensory organelles that coordinate signalling pathways in cell‐cycle control, migration, differentiation and other cellular processes critical during developmentExpand
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Directional Cell Migration and Chemotaxis in Wound Healing Response to PDGF-AA are Coordinated by the Primary Cilium in Fibroblasts
Cell motility and migration play pivotal roles in numerous physiological and pathophysiological processes including development and tissue repair. Cell migration is regulated through external stimuliExpand
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Primary Cilia and Signaling Pathways in Mammalian Development, Health and Disease
Although first described as early as 1898 and long considered a vestigial organelle of little functional importance, the primary cilium has become one of the hottest research topics in modern cellExpand
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