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Molecular basis for temperature sensing by an RNA thermometer
Regulatory RNA elements, like riboswitches, respond to intracellular signals by three‐dimensional (3D) conformational changes. RNA thermometers employ a similar strategy to sense temperature changesExpand
RNA thermometers.
Temperature is an important parameter that free-living cells monitor constantly. The expression of heat-shock, cold-shock and some virulence genes is coordinated in response to temperature changes.Expand
In vitro protein folding by E. coli ribosome: unfolded protein splitting 70S to interact with 50S subunit.
Folding of unfolded protein on Escherichia coli 70S ribosome is accompanied by rapid dissociation of the ribosome into 50S and 30S subunits. The dissociation rate of 70S ribosome with unfoldedExpand
Gene expression profiling of laser microdissected airway smooth muscle tissue in asthma and atopy
Asthma and atopy share common characteristics including type 2 helper‐T‐cell‐mediated inflammation. However, only asthma is associated with variable airways obstruction. The complex cellular andExpand
Mutations in domain V of the 23S ribosomal RNA of Bacillus subtilis that inactivate its protein folding property in vitro.
The active site of a protein folding reaction is in domain V of the 23S rRNA in the bacterial ribosome and its homologs in other organisms. This domain has long been known as the peptidyl transferaseExpand
Temperature-controlled Structural Alterations of an RNA Thermometer*
Thermoresponsive structures in the 5′-untranslated region of mRNA are known to control translation of heat shock and virulence genes. Expression of many rhizobial heat shock genes is regulated by aExpand
Complementary Role of Two Fragments of Domain V of 23 S Ribosomal RNA in Protein Folding*
We have shown that the domain V of bacterial 23 S rRNA could fold denatured proteins to their active state. This segment of 23 S rRNA could further be split into two parts. One part containing mainlyExpand
Protein folding by domain V of Escherichia coli 23S rRNA: specificity of RNA-protein interactions.
The peptidyl transferase center, present in domain V of 23S rRNA of eubacteria and large rRNA of plants and animals, can act as a general protein folding modulator. Here we show that a few specificExpand
23S rRNA assisted folding of cytoplasmic malate dehydrogenase is distinctly different from its self-folding.
The role of the 50S particle of Escherichia coli ribosome and its 23S rRNA in the refolding and subunit association of dimeric porcine heart cytoplasmic malate dehydrogenase (s-MDH) has beenExpand
Splitting of ribosome into its subunits by unfolded polypeptide chains
E. coli ribosomes can fold a number of unfolded proteins in vitro and the newly synthesized proteins in vivo. During the process of folding, the 70S ribosome is found to be dissociated into the 50SExpand
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