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Immunization with virus-like particles of enterovirus 71 elicits potent immune responses and protects mice against lethal challenge.
Peptide-based Antifungal Therapies against Emerging Infections.
A review of recent advances in peptide therapy for opportunistic fungal infections to discuss the utility and potential of selected peptides as efficient antifungal drugs with acceptable toxicity profiles.
Combination of baculovirus-mediated gene delivery and packed-bed reactor for scalable production of adeno-associated virus.
The development of a novel process for rAAV production by combining the advantages of baculovirus-mediated gene delivery and BelloCell bioreactor andBelloCell reactor culture provides a novel and economically viable approach.
Increased tumor distribution and expression of histidine-rich plasmid polyplexes
- Q. Leng, S. Chou, P. Scaria, M. Woodle, A. J. Mixson
- Biology, ChemistryThe journal of gene medicine
- 1 September 2014
Selecting nonviral carriers for in vivo gene delivery is often dependent on determining the optimal carriers from transfection assays in vitro, but many effective in vivo carriers may be overlooked by this strategy because of the marked differences between in vitro and in vivo assays.
Enhanced silencing and stabilization of siRNA polyplexes by histidine-mediated hydrogen bonds.
Surface-Modified HK:siRNA Nanoplexes with Enhanced Pharmacokinetics and Tumor Growth Inhibition
Modified HK: siRNA nanoplexes show promise to advance RNAi therapeutics in oncology and potentially other critical diseases through control of targeting ligand surface display in association with a steric PEG layer.
Demonstration of duck hepatitis B virus in bile duct epithelial cells: Implications for pathogenesis and persistent infection
- A. Nicoll, P. Angus, S. Chou, C. Luscombe, R. Smallwood, S. Locarnini
- Biology, MedicineHepatology
- 1 February 1997
The intensity of immunohistochemical staining and in situ hybridization signal in the BDEC was consistently greater than that of the hepatocytes, both before and after BDL.
Zinc Finger Nucleases: Tailor-made for Gene Therapy.
Recent advances and potential risks in zinc finger nuclease gene therapy are reviewed, finding significant promise as a therapeutic strategy for human genetic diseases, infectious diseases and oncology.
Vaccines targeting the neovasculature of tumors
Recent advances and future prospects in vaccines targeting aberrant angiogenesis of tumors targeting whole endothelial cell vaccines as well as vaccines with defined targets on endothelial cells and pericytes of the developing tumor endothelium are discussed.
Selective modification of HK peptides enhances siRNA silencing of tumor targets in vivo
- S. Chou, Q. Leng, P. Scaria, M. Woodle, A. J. Mixson
- Biology, ChemistryCancer Gene Therapy
- 5 August 2011
These studies demonstrate that selectively modified HK polymers are promising candidates for targeting oncogenes with siRNA in vitro and in vivo.