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Meis3 synergizes with Pbx4 and Hoxb1b in promoting hindbrain fates in the zebrafish.
TLDR
It is demonstrated that Meis3 synergizes with Pbx4 and Hoxb1b in promoting hindbrain fates in the zebrafish, and it is found that Hox b1b and PbX4 act together to induce ectopic hoxb 1a expression in rhombomere 2 of the hindbrain.
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Meis family proteins are required for hindbrain development in the zebrafish.
TLDR
It is shown that a divergent Meis family member, Prep1, acts as a Hox co-factor in zebrafish, and that all Meisfamily members have at least one shared function and that this function must be carried out by a conserved domain.
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Meis cofactors control HDAC and CBP accessibility at Hox-regulated promoters during zebrafish embryogenesis.
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Maternal and Zygotic aldh1a2 Activity Is Required for Pancreas Development in Zebrafish
TLDR
It is concluded that Aldh 1a2 is the primary Aldh acting during pancreas development and that maternal Aldh1a2 activity persists in aldh1 a2um22 and aldH1a 2i26 mutant embryos.
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
TLDR
A set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes are presented.
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Identification of ZBP-89 as a Novel GATA-1-Associated Transcription Factor Involved in Megakaryocytic and Erythroid Development
TLDR
These findings identify ZBP-89 as being a novel transcription factor involved in erythroid and megakaryocytic development and suggest that it serves a cooperative function with GATA-1 and/or FOG-1 in a developmental stage-specific manner.
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Pharmacological activation of NQO1 increases NAD+ levels and attenuates cisplatin-mediated acute kidney injury in mice
TLDR
Investigating the effects of increased NAD+ levels by means of NAD(P)H:quinone oxidoreductase 1 (NQO1) activation using a known pharmacological activator (β-lapachone) on cisplatin-induced renal dysfunction in vivo found it to be a promising therapeutic target.
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TALE-family homeodomain proteins regulate endodermal sonic hedgehog expression and pattern the anterior endoderm.
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A screen for hoxb1-regulated genes identifies ppp1r14al as a regulator of the rhombomere 4 Fgf-signaling center.
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Bucillamine prevents cisplatin-induced ototoxicity through induction of glutathione and antioxidant genes
TLDR
Bucillamine protects sensory hair cells from cisplatin through a scavenging effect on itself, as well as the induction of intracellular GSH, which is independent of the enzymatic activity of HO-1 and SOD.
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