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A colorimetric method for the measurement of platelet adhesion in microtiter plates.
Simultaneous evaluation of adhesion and aggregation demonstrated that with ADP as stimulus, but not with thrombin, the two platelet responses were dissociated, and platelets adhered to collagen even in the absence of stimulants.
Role of oxidative stress and antioxidants in daily nutrition and human health.
The role of quercetin, flavonols and flavones in modulating inflammatory cell function.
- S. Chirumbolo
- BiologyInflammation & allergy drug targets
- 31 August 2010
The role of flavonoids as anti-infectious and anti-inflammatory compounds is discussed, trying to focus on the complex and modulating interaction of these polyphenolic substances with cell function.
Differential response of human basophil activation markers: a multi-parameter flow cytometry approach
- S. Chirumbolo, A. Vella, P. Bellavite
- Biology, MedicineClinical and molecular allergy : CMA
- 16 October 2008
Use of polychromatic flow cytometry allowed efficient basophil electronic purification and identification of different behaviors of the major activation markers, including CD203c as a more sensitive marker than CD63, in response to fMLP but not inresponse to anti-IgE and to calcium ionophore.
Oxidative Stress in Autism Spectrum Disorder
Early assessment and treatment of antioxidant status may result in a better prognosis as it could decrease the oxidative stress in the brain before it can induce more irreversible brain damage.
Chronic fatigue syndrome (CFS): Suggestions for a nutritional treatment in the therapeutic approach.
A systematic review and meta-analysis of metal concentrations in canned tuna fish in Iran and human health risk assessment.
Adipose tissue, diet and aging
Immune dysfunction and neuroinflammation in autism spectrum disorder.
It was found that that often individuals diagnosed with ASD have alterations in immune cells such as T cells, B cells, monocytes, natural killer cells, and dendritic cells, which are key components of the diagnosis and treatment of ASD.
Bimodal action of the flavonoid quercetin on basophil function: an investigation of the putative biochemical targets
- S. Chirumbolo, M. Marzotto, A. Conforti, A. Vella, R. Ortolani, P. Bellavite
- BiologyClinical and molecular allergy : CMA
- 17 September 2010
These results rule out a possible role of protein kinase C in the complex response of basophil to quercetin, while indirectly suggest PI3K as the major intracellular target of this compound also in human basophils.