• Publications
  • Influence
Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives.
Vascular endothelial cells (ECs) are exposed to hemodynamic forces, which modulate EC functions and vascular biology/pathobiology in health and disease. The flow patterns and hemodynamic forces areExpand
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Mechanotransduction and endothelial cell homeostasis: the wisdom of the cell.
  • S. Chien
  • Biology, Medicine
  • American journal of physiology. Heart and…
  • 1 March 2007
Vascular endothelial cells (ECs) play significant roles in regulating circulatory functions. Mechanical stimuli, including the stretch and shear stress resulting from circulatory pressure and flow,Expand
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Stem cell fate dictated solely by altered nanotube dimension
Two important goals in stem cell research are to control the cell proliferation without differentiation and to direct the differentiation into a specific cell lineage when desired. Here, weExpand
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Cooperative effects of Rho and mechanical stretch on stress fiber organization.
The small GTPase Rho regulates the formation of actin stress fibers in adherent cells through activation of its effector proteins Rho-kinase and mDia. We found in bovine aortic endothelial cells thatExpand
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Activation of integrins in endothelial cells by fluid shear stress mediates Rho‐dependent cytoskeletal alignment
Fluid shear stress is a critical determinant of vascular remodeling and atherogenesis. Both integrins and the small GTPase Rho are implicated in endothelial cell responses to shear but the mechanismsExpand
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Piezo1, a mechanically activated ion channel, is required for vascular development in mice
Significance Ion channels that are activated by mechanical force have been implicated in numerous physiological systems. In mammals, the identity of these channels remains poorly understood. WeExpand
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Molecular basis of the effects of shear stress on vascular endothelial cells.
Blood vessels are constantly exposed to hemodynamic forces in the form of cyclic stretch and shear stress due to the pulsatile nature of blood pressure and flow. Endothelial cells (ECs) are subjectedExpand
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Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression
Hemodynamic shear stress is a fundamental determinant of vascular remodeling and atherogenesis. Changes in focal adhesions, cytoskeletal organization and gene expression are major responses ofExpand
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The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle.
Signaling by the mammalian target of rapamycin (mTOR) has been reported to be necessary for mechanical load-induced growth of skeletal muscle. The mechanisms involved in the mechanical activation ofExpand
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Role of integrins in endothelial mechanosensing of shear stress.
The focal pattern of atherosclerotic lesions in arterial vessels suggests that local blood flow patterns are important factors in atherosclerosis. Although disturbed flows in the branches and curvedExpand
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