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Urinary clusterin, cystatin C, β2-microglobulin and total protein as markers to detect drug-induced kidney injury
Earlier and more reliable detection of drug-induced kidney injury would improve clinical care and help to streamline drug-development. As the current standards to monitor renal function, such asExpand
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Effects of clofibric acid on mRNA expression profiles in primary cultures of rat, mouse and human hepatocytes.
The mRNA expression profile in control and clofibric acid (CLO)-treated mouse, rat, and human hepatocytes was analyzed using species-specific oligonucleotide DNA microarrays (Affymetrix). AExpand
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Gene Expression Patterns in Peripheral Blood Correlate with the Extent of Coronary Artery Disease
Systemic and local inflammation plays a prominent role in the pathogenesis of atherosclerotic coronary artery disease, but the relationship of whole blood gene expression changes with coronaryExpand
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Discovery of proteins related to coronary artery disease using industrial-scale proteomics analysis of pooled plasma.
BACKGROUND Relating a disease state to an entire population of proteins provides an opportunity to gain new insights into a disease. METHODS Male populations of 53 patients with angiographicExpand
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Pimecrolimus identifies a common genomic anti-inflammatory profile, is clinically highly effective in psoriasis and is well tolerated.
The ascomycin macrolactam pimecrolimus is a novel inflammatory cytokine release inhibitor that so far has not been administered systemically to humans. In this phase I/II randomized double-blind,Expand
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Identification of Dlk1-Dio3 imprinted gene cluster noncoding RNAs as novel candidate biomarkers for liver tumor promotion.
The molecular events during nongenotoxic carcinogenesis and their temporal order are poorly understood but thought to include long-lasting perturbations of gene expression. Here, we have investigatedExpand
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Toxicogenomics in Drug Development
Toxicogenomics represents the merging of toxicology with technologies that have been developed, together with bioinformatics, to identify and quantify global gene expression changes. It represents aExpand
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Mapping the epigenome--impact for toxicology.
Recent advances in technological approaches for mapping and characterizing the epigenome are generating a wealth of new opportunities for exploring the relationship between epigenetic modifications,Expand
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A panel of urinary biomarkers to monitor reversibility of renal injury and a serum marker with improved potential to assess renal function
The Predictive Safety Testing Consortium's first regulatory submission to qualify kidney safety biomarkers revealed two deficiencies. To address the need for biomarkers that monitor recovery fromExpand
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Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors.
The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism ofExpand
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