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Hepatocyte encapsulation for enhanced cellular functions.
TLDR
Mechanical properties of the micro Capsules measured with a nano-indentation method suggest that the microcapsules should be suitable for use in a bioartificial liver-assisted device. Expand
Optimization of 3-D hepatocyte culture by controlling the physical and chemical properties of the extra-cellular matrices.
TLDR
A specific combination of methylated and galactosylated collagen nano-fibres optimal for maintaining hepatocyte functions in vitro is identified and a model of how the physical and chemical supports interplay to maintain hepatocytes functions is discussed. Expand
Kinectin-dependent Assembly of Translation Elongation Factor-1 Complex on Endoplasmic Reticulum Regulates Protein Synthesis*
TLDR
The assembly of the elongation factor-1 complex onto endoplasmic reticulum via kinectin via EF-1δ/kinectin interaction is suggested to be important for regulating protein synthesis in eukaryotic cells. Expand
3D hepatocyte monolayer on hybrid RGD/galactose substratum.
TLDR
A hybrid RGD/galactose substratum based on polyethylene terephthalate film conjugated with both RGD peptide and galactose ligand to enhance cell adhesion and functions synergistically to be useful for various applications requiring both effective mass transfer and cellular support. Expand
Fibro-C-Index: comprehensive, morphology-based quantification of liver fibrosis using second harmonic generation and two-photon microscopy.
TLDR
A standardized, fully automated, quantification system for liver fibrosis assessment using second harmonic generation microscopy and a morphology-based quantification algorithm is developed and its potential application in clinical diagnosis to reduce inter- and intraobserver discrepancies is demonstrated. Expand
Evaluation of collagen and methylated collagen as gene carriers.
TLDR
The results suggested that gene delivery via the intramuscular route followed a different mechanism that demands a different set of physiochemical properties of the carrier from other parental routes. Expand
Galactosylated PVDF membrane promotes hepatocyte attachment and functional maintenance.
TLDR
A poly(vinylidene difluoride) (PVDF) surface coated with galactose-tethered Pluronic polymer is designed as a suitable substrate for hepatocyte culture and attached hepatocytes in spheroids exhibited higher cell functions compared to unmodified PVDF membrane and collagen-coated surface. Expand
Multi-layered microcapsules for cell encapsulation.
TLDR
Four types of multi-layered microcapsules that allow selective optimization of mechanical stability, complete encapsulation, selective permeability, and suitable extra-cellular microenvironment are developed that are suitable for tissue engineering. Expand
TGF-beta1 regulation in hepatocyte-NIH3T3 co-culture is important for the enhanced hepatocyte function in 3D microenvironment.
TLDR
Improved understanding of how co-culture enhances hepatocyte functions in vitro is improved and paved the way for further innovations in liver tissue engineering, drug metabolism studies, and other applications that require functional hepatocytes cultured in vitro. Expand
Galactosylated poly(vinylidene difluoride) hollow fiber bioreactor for hepatocyte culture.
TLDR
Morphological examination by scanning electron microscopy showed that hepatocytes cultured on galactosylated PVDF hollow fibers developed significant aggregation, in contrast to those cultured on unmodified PVDF fibers or on serum-coated PV DF fibers. Expand
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