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Deregulated Hepatic Metabolism Exacerbates Impaired Testosterone Production in Mrp4-deficient Mice*
TLDR
It is found that defective testicular testosterone production de-regulates hepatic Cyp-mediated testosterone metabolism to disrupt gametogenesis, and this has important implications for understanding the side effects of therapeutics that disrupt Mrp4 function and are reported to alter androgen production. Expand
Cyclic nucleotide compartmentalization: contributions of phosphodiesterases and ATP-binding cassette transporters.
TLDR
It has recently been discovered that ATP-binding cassette (ABC) transporters contribute to both local and global regulation of cAMP, andiphering the individual contributions of PDEs and ABCtransporters to such drug effects may lead to improved therapeutic benefits. Expand
Prostaglandin signaling regulates ciliogenesis by modulating intraflagellar transport
TLDR
It is proposed that Lkt/ABCC4-mediated PGE2 signalling acts through a ciliary G-protein-coupled receptor, EP4, to upregulate cAMP synthesis and increase anterograde IFT, thereby promoting ciliogenesis in mammalian cells. Expand
The ABCC4 membrane transporter modulates platelet aggregation.
TLDR
It is demonstrated in human platelets that ABCC4 inhibition, when coupled with phosphodiesterase inhibition, strongly impaired platelet aggregation, and this findings have important clinical implications because they directly highlight an important relationship betweenABCC4 transporter function and phosphodiesters in accounting for the cAMP-directed activity of antithrombotic agents. Expand
Metric for Measuring the Effectiveness of Clustering of DNA Microarray Expression
TLDR
The best clustering algorithm of genes must achieve cohesiveness within a cluster with respect to some biological features, and as well as maximum separation between clusters in terms of the distribution of genes of a behavioral group across clusters. Expand
Identification of a novel splice variant of X-linked inhibitor of apoptosis-associated factor 1.
TLDR
The identification of a novel splice variant of human XAF1, designatedXAF1C, which contains a cryptic exon and is predicted to encode a 164 amino acid (AA) protein lacking the C-terminal domain of the previously described XAF 1(A), but containing a unique 24 AA carboxy terminus. Expand
Human Immunodeficiency Virus Protease Inhibitors Interact with ATP Binding Cassette Transporter 4/Multidrug Resistance Protein 4: A Basis for Unanticipated Enhanced Cytotoxicity
TLDR
Results suggest that HIV-infected cancer patients receiving nelfinavir might experience both enhanced antitumor efficacy and unexpected adverse toxicity given the role of MRP4/ABCC4 in exporting nucleoside-based antiretroviral medications and cancer chemotherapeutics. Expand
Multi-drug Resistance Protein 4 (MRP4)-mediated Regulation of Fibroblast Cell Migration Reflects a Dichotomous Role of Intracellular Cyclic Nucleotides*
TLDR
It is demonstrated that mouse embryonic fibroblasts isolated from Mrp4−/− mice have higher intracellular cyclic nucleotide levels and migrate faster compared with MEFs fromMrp4+/+ mice, which provides the first experimental evidence supporting the novel concept that balance between cyclicucleotides is critical for cell migration. Expand
Retinoids and skin: Microarrays shed new light on chemopreventive action of all‐trans retinoic acid
TLDR
Comparison of the gene expression profiles of control skin to skin subjected to the two‐stage protocol for 3 wk, with or without ATRA, has shown that approximately half of the genes regulated by 12‐o‐tetradecanoylphorbol‐13‐acetate (TPA) are oppositely regulated when ATRA is coadministered with TPA. Expand
On Clustering of Genes
TLDR
This paper studies the popular hierarchal clustering algorithm and verifies how many of the genes in the same cluster share functionality and also looks into the supervised clustering method for satisfying hypotheses and viewHow many of these genes are functionally related. Expand
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