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Deregulated Hepatic Metabolism Exacerbates Impaired Testosterone Production in Mrp4-deficient Mice*
Background: The role of the ABC transporter, Mrp4, in regulating Leydig cell testosterone synthesis is unknown. Results: In a murine genetic model the absence of Mrp4 impairs testosterone productionExpand
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Cyclic nucleotide compartmentalization: contributions of phosphodiesterases and ATP-binding cassette transporters.
Cyclic nucleotides [e.g., cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP)] are ubiquitous second messengers that affect multiple cell functions from maturation of theExpand
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The ABCC4 membrane transporter modulates platelet aggregation.
Controlling the activation of platelets is a key strategy to mitigate cardiovascular disease. Previous studies have suggested that the ATP-binding cassette (ABC) transporter, ABCC4, functions inExpand
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Prostaglandin signaling regulates ciliogenesis by modulating intraflagellar transport
Cilia are microtubule-based organelles that mediate signal transduction in a variety of tissues. Despite their importance, the signalling cascades that regulate cilium formation remain incompletelyExpand
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Metric for Measuring the Effectiveness of Clustering of DNA Microarray Expression
We propose a metric to measure the effectiveness of clustering algorithms of genes by computing inter-cluster cohesiveness and as well as the intra-Cluster separation with respect to biological features such as biological processes or molecular functions. Expand
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Identification of a novel splice variant of X-linked inhibitor of apoptosis-associated factor 1.
XAF1 (XIAP-associated factor 1) binds to XIAP and blocks its anti-apoptotic activity. It has been reported that XAF1 is mainly expressed in normal tissues but is missing or present at low levels inExpand
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Human Immunodeficiency Virus Protease Inhibitors Interact with ATP Binding Cassette Transporter 4/Multidrug Resistance Protein 4: A Basis for Unanticipated Enhanced Cytotoxicity
Human immunodeficiency virus (HIV) pharmacotherapy, by combining different drug classes such as nucleoside analogs and HIV protease inhibitors (PIs), has increased HIV-patient life expectancy.Expand
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Multi-drug Resistance Protein 4 (MRP4)-mediated Regulation of Fibroblast Cell Migration Reflects a Dichotomous Role of Intracellular Cyclic Nucleotides*
Background: MRP4 is an endogenous transporter of cyclic nucleotides that can regulate cell migration. The role of MRP4 in fibroblast migration is unknown. Results: MRP4-deficient fibroblasts migrateExpand
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Retinoids and skin: Microarrays shed new light on chemopreventive action of all‐trans retinoic acid
Despite the use of retinoids in the clinic for many years, their mode of action in the prevention of skin cancer is still unclear. Recent microarray analyses of the chemopreventive effect ofExpand
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On Clustering of Genes
The availability of microarray technology at an affordable price makes it possible to determine expression of several thousand genes simultaneously. Expand
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