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  • C. Battram, S. Charlton, +9 authors A. Trifilieff
  • Chemistry, Medicine
  • Journal of Pharmacology and Experimental…
  • 2006 (First Publication: 1 May 2006)
  • Here, we describe the preclinical pharmacological profile of 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-1H-quinolin-2-one (indacaterol), a novel, chirally pure inhaled β2Expand
  • David A. Sykes, Mark R. Dowling, Steven J Charlton
  • Medicine, Chemistry
  • Molecular Pharmacology
  • 2009 (First Publication: 1 September 2009)
  • Although there are several empirical approaches that enable the comparison of relative agonist efficacy, the molecular basis that underlies differences in the ability of G protein-coupled receptorExpand
  • D. Sykes, M. R. Dowling, +5 authors S. Charlton
  • Medicine, Chemistry
  • Journal of Pharmacology and Experimental…
  • 2012 (First Publication: 1 November 2012)
  • Studies under nonphysiological conditions suggest that long receptor residency time is responsible for the 24-h duration of action of the long-acting muscarinic antagonist (LAMA) tiotropium. Our aimExpand