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Type 4 phosphodiesterase inhibitors have clinical and in vitro anti-inflammatory effects in atopic dermatitis.
- J. Hanifin, S. Chan, +4 authors E. Weiner
- The Journal of investigative dermatology
- 1 July 1996
Increased cyclic AMP-phosphodiesterase activity in peripheral blood leukocytes is associated with the immune and inflammatory hyperreactivity that characterizes atopic dermatitis. Atopic… Expand
Maintaining interactivity while exploring massive time series
- S. Chan, Ling Xiao, J. Gerth, P. Hanrahan
- Computer Science
- IEEE Symposium on Visual Analytics Science and…
- 18 November 2008
We present ATLAS, a visualization tool for temporal data that addresses these issues using a combination of high performance database technology, predictive caching, and level of detail management. Expand
In vitro studies on the morphogenesis and differentiation of the mesoderm subjacent to the apical ectodermal ridge of the embryonic chick limb-bud.
- R. Kosher, M. Savage, S. Chan
- Biology, Medicine
- Journal of embryology and experimental morphology
- 1 April 1979
It has been suggested that one of the major functions of the apical ectodermal ridge (AER) of the embryonic chick limb-bud is to maintain mesenchymal cells directly subjacent to it (i.e. cells… Expand
Increased interleukin-4 production by atopic mononuclear leukocytes correlates with increased cyclic adenosine monophosphate-phosphodiesterase activity and is reversible by phosphodiesterase…
Previous studies have shown that leukocytes from patients with atopic dermatitis have increased levels of cyclic adenosine monophosphate (cAMP)-phosphodiesterase activity. This increased activity… Expand
Abnormal skin irritancy in atopic dermatitis and in atopy without dermatitis.
BACKGROUND AND DESIGN Past observations have shown increased irritancy in patients with "conditioned hyperirritability" due to active dermatitis, including atopic dermatitis (AD). In less active… Expand
Biochemical and immunologic mechanisms in atopic dermatitis: new targets for emerging therapies.
The immunologic and pharmacophysiologic features of atopic dermatitis have stimulated research seeking to identify relevant effector cells and mediators that characterize chronic skin inflammation.… Expand
Phosphodiesterase inhibition by Ro 20-1724 reduces hyper-IgE synthesis by atopic dermatitis cells in vitro.
Peripheral blood mononuclear leukocytes (MNL) from patients with atopic dermatitis spontaneously produce large amounts of IgE in vitro. These cells also show markedly elevated levels of cAMP… Expand
Elevated leukocyte cyclic AMP-phosphodiesterase in atopic disease: a possible mechanism for cyclic AMP-agonist hyporesponsiveness.
Previous studies have documented that leukocytes from atopic individuals show reduced cyclic AMP (cAMP) responsiveness to isoproterenol, histamine, and prostaglandin E1. We questioned whether this… Expand
Increased leukocyte histamine release with elevated cyclic AMP-phosphodiesterase activity in atopic dermatitis.
- J. Butler, S. Chan, S. Stevens, J. Hanifin
- The Journal of allergy and clinical immunology
- 1 May 1983
Maximal leukocyte histamine release in response to concanavalin A was significantly higher in a group of 16 adult patients with moderate to severe atopic dermatitis when compared to 13 adult… Expand
Overexpression of IL-10 in atopic dermatitis. Contrasting cytokine patterns with delayed-type hypersensitivity reactions.
The skin lesions of patients with atopic dermatitis provide a model to study immunoregulation in human allergy. To determine the local cytokine pattern of cells present (both endogenous and… Expand