Recent progress and challenges in the discovery of new neuraminidase inhibitors
A potential pitfall in NA-based assays and the progress in the chemical synthesis of all patented NAIs from February 2006 to July 2012 are discussed, which suggest that the strategy of designing NAIs binding to the highly conserved region of NA can lead to inhibitors that are effective against all influenza NA subtypes.
Computational screening of fatty acid synthase inhibitors against thioesterase domain
- Wanwisa Panman, B. Nutho, S. Chamni, Supaporn Dokmaisrijan, N. Kungwan, T. Rungrotmongkol
- Chemistry, BiologyJournal of Biomolecular Structure and Dynamics
- 23 October 2017
The finding suggested that R34 could be a potential candidate as a novel FAS-TE inhibitor for further drug design, which showed a stronger binding affinity than MGLFP.
Beta-lactam congeners of orlistat as inhibitors of fatty acid synthase.
Indices of iron deficiency and anaemia in Bedouin and Jewish toddlers in southern Israel
- J. Urkin,, D. Adam, D. Weitzman, E. Gazala, S. Chamni, J. Kapelushnik
- Medicine, ChemistryActa paediatrica
- 27 April 2007
An attempt is made to estimate the prevalence of iron deficiency and iron deficiency anaemia using haematological indices to find out if these conditions are more common in women than in men.
Synthesis and Absolute Configuration of Acanthodendrilline, a New Cytotoxic Bromotyrosine Alkaloid from the Thai Marine Sponge Acanthodendrilla sp.
- Nachanun Sirimangkalakitti, M. Yokoya, K. Suwanborirux
- Chemistry, BiologyChemical and pharmaceutical bulletin
- 1 March 2016
Cytotoxicity evaluation revealed that (S)-1 exhibited approximately three-fold more potent cytotoxicity against the human non-small cell lung cancer H292 cell line than (R)-1.
Bromotyrosine Alkaloids with Acetylcholinesterase Inhibitory Activity from the Thai Sponge Acanthodendrilla sp
- Natchanun Sirimangkalakitti, O. Olatunji, K. Suwanborirux
- Chemistry, BiologyPlanta Medica
- 1 November 2015
A therapeutic potential for 7 in acetylcholine-related diseases, most importantly Alzheimer's disease is found, indicating its competitive mode of inhibition.
Potential Anti-metastasis Natural Compounds for Lung Cancer.
- P. Chanvorachote, S. Chamni, Chuanpit Ninsontia, P. P. Phiboonchaiyanan
- BiologyAnticancer Research
- 1 November 2016
As lung cancer is the most common malignancy worldwide and high mortalities are the result of metastasis, novel information surpassing the treatment strategies and therapeutic agents focusing on…
Synthesis of (±)-spongiolactone enabling discovery of a more potent derivative.
- N. Harvey, J. Krysiak, S. Chamni, S. Cho, S. Sieber, D. Romo
- Chemistry, BiologyChemistry
- 19 January 2015
An eleven-step synthesis of (±)-spongiolactone from 1,3-cyclohexanedione is reported that relies on a diastereoselective, nucleophile-catalyzed aldol lactonization (NCAL) process with an advanced…
Diazo reagents with small steric footprints for simultaneous arming/SAR studies of alcohol-containing natural products via O-H insertion.
- S. Chamni, Qingli He, Yongjun Dang, S. Bhat, Jun O. Liu, D. Romo
- Chemistry, BiologyACS Chemical Biology
- 28 September 2011
Novel diazo reagents for simultaneous arming and structure-activity relationship (SAR) studies of alcohol-containing natural products with a small steric footprint, namely, an α-trifluoroethyl (HTFB) substituted reagent are described.
The investigation of binary and ternary sulfobutylether-β-cyclodextrin inclusion complexes with asiaticoside in solution and in solid state.