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A scaffold-tree-merging strategy for prospective bioactivity annotation of gamma-pyrones.
Chemistry and biology of cyclic depsipeptides of medicinal and biological interest.
- F. Sarabia, S. Chammaa, A. Ruiz, L. M. Ortiz, F. J. L. Herrera
- Biology, ChemistryCurrent medicinal chemistry
- 1 May 2004
The present review deals with the most interesting aspects of the biology and the chemistry of some of the cyclic depsipeptides.
A highly efficient methodology of asymmetric epoxidation based on a novel chiral sulfur ylide.
- F. Sarabia, S. Chammaa, M. García-Castro, Francisca Martín-Gálvez
- ChemistryChemical communications
- 14 October 2009
A new type of chiral sulfur ylides has been synthesized and their reactivities against carbonyl compounds tested, showing a high degree of stereoselectivity in the formation of trans epoxy amides…
Solid phase synthesis of globomycin and SF-1902 A5.
- F. Sarabia, S. Chammaa, Cristina García-Ruiz
- Chemistry, BiologyThe Journal of organic chemistry
- 2 March 2011
The syntheses of the natural lipocyclodepsipeptide-type antibiotics globomycin and SF-1902 A(5) are reported, utilizing solid phase technology for the construction of the peptidic fragment and a new…
A highly stereoselective synthesis of glycidic amides based on a new class of chiral sulfonium salts: applications in asymmetric synthesis.
A new type of chiral sulfonium salts that are characterized by a bicyclic system has been designed and synthesized from α-amino acids and were reduced into their corresponding epoxy alcohols and subjected to oxirane-ring-opening reactions with different types of nucleophiles.
Chiral sulfur ylides for the synthesis of bengamide E and analogues.
- F. Sarabia, Francisca Martín-Gálvez, S. Chammaa, Laura Martín-Ortiz, A. Sánchez-Ruiz
- ChemistryThe Journal of organic chemistry
- 22 July 2010
A new synthetic methodology of asymmetric epoxidation developed in the laboratories has been employed for the stereoselective synthesis of bengamide E and analogues at the terminal olefinic position and allowed access to the generation of a wide array of new bENGamide analogues.
Palladium-Mediated Approach to Coumarin-Functionalized Amino Acids.
A Pd-mediated coupling is described between o-methoxyboronic acids and a glutamic acid derived (Z)-vinyl triflate, forming latent coumarins, and a mild and scalable route yielded five analogues, including a probe suitable for use at lower pH.
Isomerization of E-α,β-epoxyamides to Z-α,β-epoxyamides and synthetic applications based on regio- and stereoselective oxirane ring openings
Stereoselective synthesis of E-64 and related cysteine proteases inhibitors from 2,3-epoxyamides.