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Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-Prospective Cohort Study.
BACKGROUND We sought to provide a contemporary picture of the presentation, etiology, and outcome of infective endocarditis (IE) in a large patient cohort from multiple locations worldwide. METHODS… Expand
Incidence and characteristics of viral community-acquired pneumonia in adults
Background: In adults, viral causes of community-acquired pneumonia (CAP) are poorly characterised. The aims of this study were to characterise the viral aetiology of CAP in adults by using an… Expand
Community acquired pneumonia: aetiology and usefulness of severity criteria on admission.
BACKGROUND: Community acquired pneumonia remains an important cause of hospital admission and carries an appreciable mortality. Criteria for the assessment of severity during admission have been… Expand
HACEK Infective Endocarditis: Characteristics and Outcomes from a Large, Multi-National Cohort
The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of… Expand
Glycine betaine and glycine betaine analogues in common foods
Abstract In this study we have surveyed the betaine content of a wide range of foods commonly found in the western diet. Glycine betaine, proline betaine (stachydrine), trigonelline and… Expand
Concomitant Staphylococcus aureus bacteriuria is associated with poor clinical outcome in adults with S. aureus bacteraemia.
- P. Huggan, D. Murdoch, K. Gallagher, S. Chambers
- The Journal of hospital infection
- 1 August 2008
A retrospective cohort study was undertaken to determine the prognostic significance of Staphylococcus aureus bacteriuria in patients presenting to our hospital with S. aureus bacteraemia between… Expand
Association between HACEK bacteraemia and endocarditis.
We retrospectively examined medical records of 87 patients with bacteraemia caused by members of the HACEK group (Haemophilus parainfluenzae, Aggregatibacter actinomycetemcomitans, Aggregatibacter… Expand
Betaine and Trimethylamine-N-Oxide as Predictors of Cardiovascular Outcomes Show Different Patterns in Diabetes Mellitus: An Observational Study
Background Betaine is a major osmolyte, also important in methyl group metabolism. Concentrations of betaine, its metabolite dimethylglycine and analog trimethylamine-N-oxide (TMAO) in blood are… Expand
Evaluation of a PCR Assay for Detection of Streptococcus pneumoniae in Respiratory and Nonrespiratory Samples from Adults with Community-Acquired Pneumonia
- D. Murdoch, T. Anderson, +7 authors L. Jennings
- Biology, Medicine
- Journal of Clinical Microbiology
- 1 January 2003
ABSTRACT Streptococcus pneumoniae is the most common cause of community-acquired pneumonia, but it is undoubtedly underdiagnosed. We used a nested PCR assay (targeting the pneumolysin gene) to detect… Expand
Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure.
- D. Mcgregor, W. J. Dellow, R. Robson, M. Lever, P. George, S. Chambers
- Kidney international
- 1 March 2002
BACKGROUND Fasting and post-methionine load hyperhomocysteinemia are independent risk factors for vascular disease that are common in chronic renal failure. Folate decreases but seldom normalizes… Expand