S. Chambers

Publications236
h-index50
Citations8,552
Highly Influential Citations315
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Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-Prospective Cohort Study.
BACKGROUND We sought to provide a contemporary picture of the presentation, etiology, and outcome of infective endocarditis (IE) in a large patient cohort from multiple locations worldwide. METHODS… Expand
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Incidence and characteristics of viral community-acquired pneumonia in adults
Background: In adults, viral causes of community-acquired pneumonia (CAP) are poorly characterised. The aims of this study were to characterise the viral aetiology of CAP in adults by using an… Expand
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Community acquired pneumonia: aetiology and usefulness of severity criteria on admission.
BACKGROUND: Community acquired pneumonia remains an important cause of hospital admission and carries an appreciable mortality. Criteria for the assessment of severity during admission have been… Expand
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HACEK Infective Endocarditis: Characteristics and Outcomes from a Large, Multi-National Cohort
The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of… Expand
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Glycine betaine and glycine betaine analogues in common foods
Abstract In this study we have surveyed the betaine content of a wide range of foods commonly found in the western diet. Glycine betaine, proline betaine (stachydrine), trigonelline and… Expand
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Concomitant Staphylococcus aureus bacteriuria is associated with poor clinical outcome in adults with S. aureus bacteraemia.
A retrospective cohort study was undertaken to determine the prognostic significance of Staphylococcus aureus bacteriuria in patients presenting to our hospital with S. aureus bacteraemia between… Expand
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Association between HACEK bacteraemia and endocarditis.
We retrospectively examined medical records of 87 patients with bacteraemia caused by members of the HACEK group (Haemophilus parainfluenzae, Aggregatibacter actinomycetemcomitans, Aggregatibacter… Expand
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Betaine and Trimethylamine-N-Oxide as Predictors of Cardiovascular Outcomes Show Different Patterns in Diabetes Mellitus: An Observational Study
Background Betaine is a major osmolyte, also important in methyl group metabolism. Concentrations of betaine, its metabolite dimethylglycine and analog trimethylamine-N-oxide (TMAO) in blood are… Expand
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Evaluation of a PCR Assay for Detection of Streptococcus pneumoniae in Respiratory and Nonrespiratory Samples from Adults with Community-Acquired Pneumonia
ABSTRACT Streptococcus pneumoniae is the most common cause of community-acquired pneumonia, but it is undoubtedly underdiagnosed. We used a nested PCR assay (targeting the pneumolysin gene) to detect… Expand
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Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure.
BACKGROUND Fasting and post-methionine load hyperhomocysteinemia are independent risk factors for vascular disease that are common in chronic renal failure. Folate decreases but seldom normalizes… Expand
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