A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells.
- J. Yook, Xiao-yan Li, S. Weiss
- Biology, MedicineNature Cell Biology
- 2006
It is demonstrated that canonical Wnt signalling engages tumour cell dedifferentiation and tissue-invasive activity through an Axin2-dependent pathway that stabilizes the Snail1 zinc-transcription factor, a key regulator of normal and neoplastic EMT programmes.
Snail1 is stabilized by O‐GlcNAc modification in hyperglycaemic condition
- Sang Yoon Park, Hyun Sil Kim, J. Cho
- BiologyEMBO Journal
- 17 November 2010
It is shown that by suppressing O‐phosphorylation‐mediated degradation, O‐GlcNAc at serine112 stabilizes Snail1 and thus increases its repressor function, which in turn attenuates E‐cadherin mRNA expression.
A Wnt–Axin2–GSK3β cascade regulates Snail1 activity in breast cancer cells
- J. Yook, Xiao-yan Li, S. Weiss
- BiologyNature Cell Biology
- 1 December 2006
It is demonstrated that canonical Wnt signalling engages tumour cell dedifferentiation and tissue-invasive activity through an Axin2-dependent pathway that stabilizes the Snail1 zinc-transcription factor, a key regulator of normal and neoplastic EMT programmes.
p53 and MicroRNA-34 Are Suppressors of Canonical Wnt Signaling
- N. Kim, Hyun Sil Kim, S. Weiss
- BiologyScience Signaling
- 1 November 2011
P53 transactivated microRNA-34 (miR-34), which consequently suppressed the transcriptional activity of β-catenin–T cell factor and lymphoid enhancer factor (TCF/LEF) complexes by targeting the untranslated regions (UTRs) of a set of conserved targets in a network of genes encoding elements of the Wnt pathway.
A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial–mesenchymal transition
- N. Kim, Hyun Sil Kim, J. Yook
- Biology, MedicineJournal of Cell Biology
- 31 October 2011
Expression of the essential EMT inducer Snail1 is inhibited by miR-34 through a p53-dependent regulatory pathway.
Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress
- N. Kim, Y. Cha, Hyun Sil Kim
- BiologyNature Communications
- 8 February 2017
It is shown that Snail (SNAI1), a key transcriptional repressor of EMT, regulates glucose flux toward PPP, allowing cancer cell survival under metabolic stress and increases metastatic capacities in vivo.
Genetic Drift, Not Life History or RNAi, Determine Long-Term Evolution of Transposable Elements
- Amir Szitenberg, S. Cha, C. Opperman, D. Bird, M. Blaxter, D. Lunt
- BiologyGenome Biology and Evolution
- 26 August 2016
Although statistical power to detect selection is demonstrated, there is no evidence that variation in these factors influence genomic TE loads across extended periods of time, and the effects of genetic drift appear to persist and control TE variation among species.
Helicobacter pylori CagA promotes Snail-mediated epithelial-mesenchymal transition by reducing GSK-3 activity.
- Da-Gyum Lee, Hyun Sil Kim, Y. C. Lee
- BiologyNature Communications
- 23 July 2014
Results suggest that H. pylori CagA acts as a pathogenic scaffold protein that induces a Snail-mediated EMT via the depletion of GSK-3 through the binding of Axin and the shift to an insoluble fraction.
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