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Evidence of link between quorum sensing and sugar metabolism in Escherichia coli revealed via cocrystal structures of LsrK and HPr
AI-2–mediated quorum sensing of E. coli is directly connected to sugar metabolism via the phosphocarrier HPr protein of PTS. Quorum sensing (QS), a bacterial process that regulates population-scale… Expand
Structural Basis for Cell-Wall Recognition by Bacteriophage PBC5 Endolysin.
Phage endolysins are hydrolytic enzymes that cleave the bacterial cell wall during the lytic cycle. We isolated the bacteriophage PBC5 against Bacillus cereus, a major foodborne pathogen, and… Expand
Determinants of PB1 Domain Interactions in Auxin Response Factor ARF5 and Repressor IAA17.
- Youngim Kim, Changkon Park, S. Cha, Mookyoung Han, K. Ryu, J. Suh
- Chemistry, Medicine
- Journal of molecular biology
- 16 April 2020
Auxin is a plant hormone that is central to plant growth and development from embryogenesis to senescence. Auxin signaling is mediated by auxin response transcription factors (ARFs) and Aux/IAA… Expand
Total Synthesis of Xanthoangelol B and Its Various Fragments: Toward Inhibition of Virulence Factor Production of Staphylococcus aureus
- Pushpak Mizar, Rekha Arya, +8 authors S. S. Lee
- Chemistry, Medicine
- Journal of medicinal chemistry
- 2 November 2018
As an alternative strategy to fight antibiotic resistance, two-component systems (TCSs) have emerged as novel targets. Among TCSs, master virulence regulators that control the expression of multiple… Expand
NMR mapping of the highly flexible regions of 13C/15N-labeled antibody TTAC-0001-Fab.
Monoclonal antibody (mAb) drugs are clinically important for the treatment of various diseases. TTAC-0001 is under development as a new anti-cancer antibody drug targeting VEGFR-2. As the less severe… Expand
Zinc-mediated Reversible Multimerization of Hsp31 Enhances the Activity of Holding Chaperone.
Hsp31 protein, belonging to the DJ-1/ThiJ/PfpI superfamily, increases the survival of Escherichia coli under various stresses. While it was reported as a holding chaperone, Hsp31 was also shown to… Expand