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Evidence of link between quorum sensing and sugar metabolism in Escherichia coli revealed via cocrystal structures of LsrK and HPr
AI-2–mediated quorum sensing of E. coli is directly connected to sugar metabolism via the phosphocarrier HPr protein of PTS. Quorum sensing (QS), a bacterial process that regulates population-scaleExpand
Structural Basis for Cell-Wall Recognition by Bacteriophage PBC5 Endolysin.
Phage endolysins are hydrolytic enzymes that cleave the bacterial cell wall during the lytic cycle. We isolated the bacteriophage PBC5 against Bacillus cereus, a major foodborne pathogen, andExpand
Determinants of PB1 Domain Interactions in Auxin Response Factor ARF5 and Repressor IAA17.
Auxin is a plant hormone that is central to plant growth and development from embryogenesis to senescence. Auxin signaling is mediated by auxin response transcription factors (ARFs) and Aux/IAAExpand
Total Synthesis of Xanthoangelol B and Its Various Fragments: Toward Inhibition of Virulence Factor Production of Staphylococcus aureus
As an alternative strategy to fight antibiotic resistance, two-component systems (TCSs) have emerged as novel targets. Among TCSs, master virulence regulators that control the expression of multipleExpand
ARF5 Aux/IAA17 Complex
NMR mapping of the highly flexible regions of 13C/15N-labeled antibody TTAC-0001-Fab.
  • S. Cha, W. Lee, +7 authors K. Ryu
  • Chemistry, Medicine
  • Journal of biomolecular NMR
  • 15 May 2020
Monoclonal antibody (mAb) drugs are clinically important for the treatment of various diseases. TTAC-0001 is under development as a new anti-cancer antibody drug targeting VEGFR-2. As the less severeExpand
Zinc-mediated Reversible Multimerization of Hsp31 Enhances the Activity of Holding Chaperone.
Hsp31 protein, belonging to the DJ-1/ThiJ/PfpI superfamily, increases the survival of Escherichia coli under various stresses. While it was reported as a holding chaperone, Hsp31 was also shown toExpand