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Diagnosis of polycystic ovary syndrome (PCOS): revisiting the threshold values of follicle count on ultrasound and of the serum AMH level for the definition of polycystic ovaries.
TLDR
For the definition of PCOM, the former threshold of >12 for FN is no longer valid and a serum AMH >35 pmol/l appears to be more sensitive and specific than a FN >19 and should be included in the current diagnostic classifications for PCOS. Expand
Novel role for anti-Müllerian hormone in the regulation of GnRH neuron excitability and hormone secretion
TLDR
It is demonstrated that a significant subset of GnRH neurons both in mice and humans express the AMH receptor, and that AMH potently activates the GnRH neuron firing in mice, supporting a central action of AMH on Gn RH neurons. Expand
Oligoanovulation with polycystic ovaries but not overt hyperandrogenism.
TLDR
Oligoanovulatory patients with PCO but without HA have mild endocrine and metabolic features of PCOS, according to the Rotterdam definition. Expand
Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood
TLDR
A critical role is highlighted for excess prenatal AMH exposure and subsequent aberrant GnRH receptor signaling in the neuroendocrine dysfunctions of PCOS, while offering a new potential therapeutic avenue to treat the condition during adulthood. Expand
Reconciling the definitions of polycystic ovary syndrome: the ovarian follicle number and serum anti-Müllerian hormone concentrations aggregate with the markers of hyperandrogenism.
TLDR
It is hypothesized that excessive follicle number assessed by ovarian ultrasonography and/or serum anti-Müllerian hormone concentrations may be used as surrogates for the classical markers of HA, which reconciles the Rotterdam Consensus and other definitions for PCOS. Expand
Materno-Fetal Cardiovascular Complications in Turner Syndrome after Oocyte Donation: Insufficient Prepregnancy Screening and Pregnancy Follow-Up Are Associated with Poor Outcome.
TLDR
Results: Among 93 patients, only 37.6% were prescreened with echocardiography or thoracic magnetic resonance imaging, and only 40% of pregnancies were associated with an absolutely normal materno-fetal outcome. Expand
Role of Anti-Müllerian Hormone in pathophysiology, diagnosis and treatment of Polycystic Ovary Syndrome: a review
TLDR
This review will explain the utility of serum AMH assay in the management of infertility in women with PCOS and its utility as a marker of treatment efficiency on PCOS symptoms and the lack of an international standard makes it difficult to define consensual thresholds, and thus impairs the widespread use of this new ovarian marker. Expand
Interactions between androgens, FSH, anti-Müllerian hormone and estradiol during folliculogenesis in the human normal and polycystic ovary.
TLDR
The two triangles hypothesis, based on updated data from the literature, offers a pedagogic template for the understanding of folliculogenesis in the normal and polycystic ovary and opens new avenues for the treatment of anovulation due to PCOS. Expand
FSH and its second messenger cAMP stimulate the transcription of human anti-Müllerian hormone in cultured granulosa cells.
TLDR
It is shown that FSH and cAMP enhance AMH transcription, and LH has an additive effect and the expression profile of AMH and the dynamics of serum AMH after gonadotropin stimulation have been interpreted as a down-regulating effect of FSH upon AMH production by granulosa cells. Expand
Use of the serum anti-Müllerian hormone assay as a surrogate for polycystic ovarian morphology: impact on diagnosis and phenotypic classification of polycystic ovary syndrome
TLDR
The results suggest that ideally both U/S data and serum AMH level should be integrated to define PCOM in the Rotterdam classification, and the choice of one or the other has little impact on the diagnosis and the phenotyping of PCOS. Expand
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