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Targeting the dopamine D1 receptor in schizophrenia: insights for cognitive dysfunction
TLDR
This review examines the role of dopamine in regulating cellular and circuit function within prefrontal cortex in order to understand the significance of the dopamine dysregulation found in schizophrenia and related non-human primate models. Expand
Sex differences in striatal dopamine: in vivo microdialysis and behavioral studies
TLDR
There are sex differences in striatal extracellular dopamine and in the effect of estrogen on the striatal dopamine neurochemical and behavioral responses to amphetamine. Expand
Reversal of antipsychotic-induced working memory deficits by short-term dopamine D1 receptor stimulation.
TLDR
Findings indicate that pharmacological modulation of the D1 signaling pathway can produce long-lasting changes in functional circuits underlying working memory and may provide a valuable strategy for therapeutic intervention in schizophrenia and other dopamine dysfunctional states. Expand
Antipsychotic treatment induces alterations in dendrite- and spine-associated proteins in dopamine-rich areas of the primate cerebral cortex
TLDR
It is demonstrated that long-term haloperidol exposure alters neuronal cytoskeleton- and spine-associated proteins, particularly in dopamine-rich regions of the primate cerebral cortex, many of which have been implicated in the psychopathology of schizophrenia. Expand
Animal models of working memory: insights for targeting cognitive dysfunction in schizophrenia
TLDR
This review examines the key rodent and non-human primate models for elucidating the neural mechanisms of working memory and their neuromodulation and evaluates their relevance for schizophrenia. Expand
Under the curve: Critical issues for elucidating D1 receptor function in working memory
TLDR
The hypothesis that the window of optimal dopamine signaling changes on a behavioral time-scale, dependent upon current cognitive demands and local neuronal activity as well as long-term alterations in signaling pathways and gene expression is explored. Expand
Tuning the engine of cognition: A focus on NMDA/D1 receptor interactions in prefrontal cortex
TLDR
The evidence is critically outlined that the integration of these processes and, in particular, the induction and maintenance of persistent activity in prefrontal cortex and related networks, is dependent upon the interaction of dopamine D1 and glutamate NMDA receptor signaling at critical nodes within local circuits and distributed networks. Expand
Enhancement of Working Memory in Aged Monkeys by a Sensitizing Regimen of Dopamine D1 Receptor Stimulation
TLDR
It is reported that an intermittent, sensitizing regimen of the D1 dopamine agonist ABT-431 dramatically enhances working memory performance in aged rhesus monkeys, while either producing impairment or having little effect on performance in young adult monkeys. Expand
Neuroplasticity as a target for the pharmacotherapy of anxiety disorders, mood disorders, and schizophrenia.
TLDR
In considering neuroplasticity as a target for the treatment of psychiatric disorders, this review builds on exciting new findings in the areas of anxiety disorders, mood disorders, and schizophrenia. Expand
Amphetamine Sensitization Alters Dendritic Morphology in Prefrontal Cortical Pyramidal Neurons in the Non-Human Primate
TLDR
It is indicated that chronic dopamine dysregulation, consequent to AMPH sensitization, results in enduring, atrophic changes in prefrontal pyramidal dendrites that resemble the pathologic alterations described in patients with schizophrenia and may contribute to the persistence of schizophrenia-like behavioral changes and cognitive dysfunction associated with sensitization. Expand
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