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Regulation of the Germinal Center Response by MicroRNA-155
MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the evolutionarily conserved microRNA-155 (miR-155)Expand
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Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination
B cells producing high-affinity antibodies are destined to differentiate into memory B cells and plasma cells, but the mechanisms leading to those differentiation pathways are mostly unknown. Here weExpand
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Jmjd3 contributes to the control of gene expression in LPS-activated macrophages
Jmjd3, a JmjC family histone demethylase, is induced by the transcription factor NF‐kB in response to microbial stimuli. Jmjd3 erases H3K27me3, a histone mark associated with transcriptionalExpand
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  • Open Access
TNF Family Member B Cell-Activating Factor (BAFF) Receptor-Dependent and -Independent Roles for BAFF in B Cell Physiology1
The cytokine TNF family member B cell-activating factor (BAFF; also termed BLyS) is essential for B cell generation and maintenance. Three receptors have been identified that bind to BAFF:Expand
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Plasma cells require autophagy for sustainable immunoglobulin production
The role of autophagy in plasma cells is unknown. Here we found notable autophagic activity in both differentiating and long-lived plasma cells and investigated its function through the use of miceExpand
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Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis.
Protection against deadly pathogens requires the production of high-affinity antibodies by B cells, which are generated in germinal centers (GCs). Alteration of the GC developmental program is commonExpand
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  • Open Access
Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis.
Fas is highly expressed in activated and germinal center (GC) B cells but can potentially be inactivated by misguided somatic hypermutation. We employed conditional Fas-deficient mice to investigateExpand
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Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting.
Germinal centers (GCs) represent the main sites for the generation of high-affinity, class-switched antibodies during T cell-dependent antibody responses. To study gene function specifically in GC BExpand
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  • Open Access
B cell receptor signal strength determines B cell fate
B cell receptor (BCR)-mediated antigen recognition is thought to regulate B cell differentiation. BCR signal strength may also influence B cell fate decisions. Here, we used the Epstein-Barr virusExpand
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