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Reach and grasp by people with tetraplegia using a neurally controlled robotic arm
We demonstrate the ability of two people with long-standing tetraplegia to use neural interface system-based control of a robotic arm to perform three-dimensional reach and grasp movements. Expand
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Single-neuron dynamics in human focal epilepsy
Epileptic seizures are traditionally characterized as the ultimate expression of monolithic, hypersynchronous neuronal activity arising from unbalanced runaway excitation. Here we report the firstExpand
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Rapid fragmentation of neuronal networks at the onset of propofol-induced unconsciousness
The neurophysiological mechanisms by which anesthetic drugs cause loss of consciousness are poorly understood. Anesthetic actions at the molecular, cellular, and systems levels have been studied inExpand
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The Human K-Complex Represents an Isolated Cortical Down-State
Down But Not Out The K-complex, a defining characteristic of slow wave sleep, is the largest spontaneously occurring component of the healthy human electroencephalogram (EEG) but little is knownExpand
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Mechanisms of Calcium Influx into Hippocampal Spines: Heterogeneity among Spines, Coincidence Detection by NMDA Receptors, and Optical Quantal Analysis
Dendritic spines receive most excitatory inputs in the vertebrate brain, but their function is still poorly understood. Using two-photon calcium imaging of CA1 pyramidal neurons in rat hippocampalExpand
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Coalescence and Fragmentation of Cortical Networks during Focal Seizures
Epileptic seizures reflect a pathological brain state characterized by specific clinical and electrical manifestations. The proposed mechanisms are heterogeneous but united by the supposition thatExpand
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Linear Summation of Excitatory Inputs by CA1 Pyramidal Neurons
A fundamental problem in neurobiology is understanding the arithmetic that dendrites use to integrate inputs. The impact of dendritic morphology and active conductances on input summation is stillExpand
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Neurophysiological dynamics of phrase-structure building during sentence processing
We used human intracranial recordings and visual word-by-word presentation of sentences and word lists to investigate how left-hemispheric brain activity varies during the formation of phrase structures. Expand
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Long-term treatment with responsive brain stimulation in adults with refractory partial seizures
Objective: The long-term efficacy and safety of responsive direct neurostimulation was assessed in adults with medically refractory partial onset seizures. Methods: All participants were treated withExpand
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Emergence of Stable Functional Networks in Long-Term Human Electroencephalography
Functional connectivity networks have become a central focus in neuroscience because they reveal key higher-dimensional features of normal and abnormal nervous system physiology. Functional networksExpand
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