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Regulation of p53 stability and function by the deubiquitinating enzyme USP42
The p53 tumour suppressor protein is a transcription factor that prevents oncogenic progression by activating the expression of apoptosis and cell‐cycle arrest genes in stressed cells. The stabilityExpand
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Gender differences in carbohydrate loading are related to energy intake.
We demonstrated that female endurance athletes did not increase their muscle glycogen concentration after an increase in the dietary carbohydrate intake (58 --> 74%), whereas men did (Tarnopolsky MA,Expand
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p53-Ubl fusions as models of ubiquitination, sumoylation and neddylation of p53
The tumour suppressor p53 has been shown to be modified at its C-terminus with ubiquitin and the ubiquitin-like proteins SUMO and NEDD8. Whereas monoubiquitination of p53 is strongly associated withExpand
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MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity
The tumor suppressor p53 is extensively regulated by post-translational modification, including modification by the small ubiquitin-related modifier SUMO. We show here that MDM2, previously shown toExpand
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Comparison of echocardiographic variables between type I diabetics and normal controls.
This report compares echocardiographic estimates of systolic and diastolic function and ventricular dimensions in type I diabetics and normal controls. A random sample of 60 diabetics selected from aExpand
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A role for Numb in p53 stabilization
The cell-fate determinant Numb has recently been shown to help activate the tumor suppressor protein p53. Loss of Numb in breast cancers would result, therefore, in both the activation of theExpand
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Urinary fluoride as an exposure index in aluminum smelting.
Urinary fluoride was evaluated as an exposure index for a prospective study of asthma in an aluminum smelter. Two studies were conducted to evaluate the relationship between airborne exposure andExpand
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Endosomal dynamics of Met determine signaling output.
Proteasomal activity is required for Met receptor degradation after acute stimulation with hepatocyte growth factor (HGF). Inhibition of proteasomal activity with lactacystin leads to a block in theExpand
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Quantitation of aldosterone in human plasma by ultra high performance liquid chromatography tandem mass spectrometry.
Aldosterone is a mineralocorticoid steroid hormone whose measurement in the clinical laboratory is principally performed for the investigation of primary hyperaldosteronism. Traditionally measurementExpand
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Sonographic detection of acute parenchymal injury in an experimental porcine model of renal hemorrhage: gray-scale imaging using a sonographic contrast agent.
OBJECTIVE The purpose of this study was to determine the usefulness of contrast-enhanced sonography in the detection of acute parenchymal injury. SUBJECTS AND METHODS In a model of acute renalExpand
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