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Defective Opsonic Activity of Peritoneal Effluent during Continuous Ambulatory Peritoneal Dialysis (CAPD): Importance and Prevention
TLDR
Treatment with intraperitoneal intmunoglobulin raised PDE opsonized capacity and lowered the incidence in those with previous HPI, thus demonstrating the importance of abnormal opsonization in CAPD peritonitis and the possibility of preventing infection by prophylaxis with intra peritoneal immunoglobulus. Expand
Effect of monophosphoryl lipid A on the in vitro function of peritoneal leukocytes from uremic patients on continuous ambulatory peritoneal dialysis
TLDR
Peritoneal leukocyte dysfunction observed in patients undergoing continuous ambulatory peritoneal dialysis and who have high rates of peritonitis may be alleviated, to some degree, by MPL, without directly inducing a potentially deleterious fibrotic lesion. Expand
In Vitro and in Vivo Studies of Erythropoiesis during Continuous Ambulatory Peritoneal Dialysis
TLDR
A rise in hematocrit, hemoglobin and reticulocyte values showed a significant correlation with a recovery of the erythroid cell proliferative activity, and the improvement of bone-marrow function appears to be due to a better clearance (by CAPD) of substances, which inhibit the response of bone marrow to the ERYthropoietin. Expand
Immunologic patterns in CAPD patients with peritonitis.
Alterations of peritoneal defense mechanisms, i.e. opsonization, phagocytosis, and bacterial killing, may be responsible for the high peritonitis rate in a subgroup of CAPD patients. PeritonitisExpand
Immunological defenses in CAPD.
TLDR
It has been demonstrated that peritonitis incidence and in vitro opsonization of bacteria are related to the concentration of IgG in the dialysate and to the ability of macrophages to produce fibronectin, and it may be possible to treat patients using IgG and interferon-alpha intraperitoneally. Expand
Peritoneal Dialysis Solution pH and Ca2+ Concentration Regulate Peritoneal Macrophage and Mesothelial Cell Activation
TLDR
It is concluded that bibarbonate buffered PDS in more biocompatible than conventional PDS having a 5.5 pH, because it maintains adequate concentrations of Ca2+ in the cytoplasm of PM0 and PMC and therefore adequate cytokine release. Expand
Peritoneal dialysis fluid (PDF) C++ and 1,25(OH)2D3 modulate peritoneal macrophage (PM0) antimicrobial activity in CAPD patients.
TLDR
In vivo results confirm the importance of Ca++ and 1,25(OH)2D3 in PMO antibacterial functions in CAPD patients and may be useful in the prophylaxis and therapy of peritonitis. Expand
Intraperitoneal verapamil therapy in CAPD patients with peritoneal hypopermeability. Effects on ultrafiltration.
TLDR
In conclusion, IP verapamil can be considered a suitable therapy for increasing UF volume in CAPD patients with peritoneal hypopermeability due to a lymphomonokine-mediated hyperproliferation ofperitoneal fibroblasts. Expand
Effect of monophosphoryl lipid A (MPLA) on peritoneal leukocyte function.
TLDR
Peritoneal leukocyte abnormalities observed in some high peritonitis rate CAPD patients may be reversed, to some degree, by MPLA, without directly inducing a potentially deleterious peritoneal fibrosis. Expand
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